{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:58:16Z","timestamp":1790913496263,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":139,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin K (VK) prophylaxis refers to the administration of VK to newborns to prevent neonatal VK deficiency bleeding (VKDB), which is characterized by intracranial hemorrhage (ICH). This study investigated the relationship between VK prophylaxis methods and VKDB in biliary atresia (BA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The survey targeted 497 cases in the Japanese Biliary Atresia Registry between 2015 and 2019, of which 395 (79.5%) returned the questionnaire. Of the 395 patients, 289 were selected after excluding cases in which the gestational age was &lt;36\u2009weeks or the VK prophylaxis methods\/feeding contents were unknown. The patients were categorized into two groups according to VK prophylaxis methods. We conducted a comparative study using propensity score matching. The prognosis of patients with or without ICH was also investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the analysis, no VKDB occurred in patients using the 3\u2010month method. In the propensity score matching analysis, age at first visit and age at surgery were later in the three\u2010times method (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022, respectively); VKDB was higher in the three\u2010times method than in the 3\u2010month method (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029). ICH, jaundice disappearance, cholangitis, and native liver survival rates (NLSRs) were not significantly different between groups. When examining the prognosis based on ICH occurrence, the two groups showed no significant differences in jaundice disappearance, cholangitis, and NLSRs. The ICH group had a greater number of cases of delayed mental and\/or motor development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In BA, the 3\u2010month method is effective in preventing VKDB, and early diagnosis is crucial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70075","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T06:37:42Z","timestamp":1747723062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Vitamin K deficiency bleeding and optimal prophylaxis methods in biliary atresia: A surveillance study in Japan"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8405-1902","authenticated-orcid":false,"given":"Ryuji","family":"Okubo","sequence":"first","affiliation":[{"name":"The Japanese Biliary Atresia Society, The Office of the Japanese Biliary Atresia Society  Sendai Japan"},{"name":"Department of Pediatric Surgery Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyoe","family":"Shirota","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoshi","family":"Wada","sequence":"additional","affiliation":[{"name":"The Japanese Biliary Atresia Society, The Office of the Japanese Biliary Atresia Society  Sendai Japan"},{"name":"Department of Pediatric Surgery Tohoku University Graduate School of Medicine  Sendai 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Children's Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9069-9367","authenticated-orcid":false,"given":"Toshiharu","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8886-2515","authenticated-orcid":false,"given":"Shigehisa","family":"Fumino","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Odaka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Saitama Medical Center Saitama Medical University  Saitama 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