{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:59:15Z","timestamp":1790913555314,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":223,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Differences in infection prevention methods and their corresponding effects on patients with inborn errors of immunity (IEI) between departments that treat patients with IEI and other departments, such as local hospitals, are not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared the differences in infection prevention methods between low\u2010volume departments (treating fewer than 20 patients with IEI) and high\u2010volume departments (treating 20 or more patients with IEI) using recent nationwide survey data from Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was an uneven distribution of IEI categories between low\u2010 and high\u2010volume departments. High\u2010volume departments have set higher target trough levels for immunoglobulin replacement therapy in patients with BTK deficiency and those who have undergone transplantation. Furthermore, sulfamethoxazole\u2010trimethoprim and itraconazole were used more frequently in high\u2010volume departments for patients with hyper\u2010IgE syndrome. Additionally, more patients with common variable immunodeficiency in high\u2010volume departments received inactivated vaccines, whereas low\u2010volume departments used macrolides more frequently than prophylactic antibiotics. Overall, infection prevention management appeared to be relatively similar in low\u2010 and high\u2010volume departments. However, there were some notable differences in the specific practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The latest and most optimal infection control methods must be shared with every department where patients with IEI are treated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70093","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T08:57:26Z","timestamp":1754989046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infection prevention in patients with inborn errors of immunity: Insights from Japan's nationwide study"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-3689","authenticated-orcid":false,"given":"Zhijian","family":"Yao","sequence":"first","affiliation":[{"name":"Doctoral Program in Medical Sciences Graduate School of Comprehensive Human Sciences, University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7166-1370","authenticated-orcid":false,"given":"Takahiro","family":"Kido","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Tsukuba Hospital  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Hosaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Tsukuba Hospital  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Imagawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Tsukuba Hospital  Tsukuba Japan"},{"name":"Department of Child Health, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-3501","authenticated-orcid":false,"given":"Hiroko","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Tsukuba Hospital  Tsukuba Japan"},{"name":"Department of Child Health, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Morio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokyo Medical and Dental University Graduate School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Nonoyama","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Defense Medical College  Tokorozawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Tsukuba Hospital  Tsukuba Japan"},{"name":"Department of Child Health, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-018-0290-5"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-020-02131-9"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-022-01289-3"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9751-7"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04023.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu646"},{"key":"e_1_2_13_8_1","first-page":"249","article-title":"Prevention of infection in children and adolescents with primary immunodeficiency 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