{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:15:49Z","timestamp":1791605749753,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":182,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between Grave's disease (GD) and psychiatric symptoms is unclear in children and adolescents. Assessment of psychiatric symptoms in GD is important, especially when they occur in the absence of classic symptoms such as sweating and diffuse goiter. The present two studies aimed to assess the frequency and clinical characteristics of psychiatric symptoms in children and adolescents with GD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Study 1 was a multicentric, retrospective study while Study 2 was a monocentric, prospective, observational study. In Study 1, the participants were 135 children and adolescents aged 4\u2009years to 16\u2009years in whom GD was newly diagnosed. The frequency of psychiatric symptoms was the primary outcome. In Study 2, the participants were 14 children and adolescents aged 4\u2009years to 16\u2009years in whom GD was clinically diagnosed. Psychiatric symptoms were evaluated using various scales, and their clinical characteristics were treated as the primary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty\u2010three participants (61%) in Study 1 and five participants (36%) in Study 2 had psychiatric symptoms. Attention\u2010deficit\/hyperactivity disorder (ADHD)\u2014like symptoms were the most common presentation. Subjective improvement of the psychiatric symptoms began one to two months after the start of GD treatment, but objective improvement proceeded slowly in Study 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Psychiatric symptoms were common in children and adolescents with GD, with ADHD\u2010like symptoms being the most common presentation. Improvement of the psychiatric symptoms did not coincide with improvement of the free thyroxine value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70134","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T03:25:41Z","timestamp":1751426741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Psychiatric symptoms in children and adolescents with Graves' disease: A retrospective study and a prospective study"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7727-7361","authenticated-orcid":false,"given":"Rie","family":"Kuge","sequence":"first","affiliation":[{"name":"Mental Health Clinic for Children Shinshu University Hospital  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1810-9894","authenticated-orcid":false,"given":"Koji","family":"Muroya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Kanagawa Children's Medical Center  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Saitama Prefectural Children's Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5882-661X","authenticated-orcid":false,"given":"Keisuke","family":"Nagasaki","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Department of Homeostatic Regulation and Development Niigata University Graduate School of Medical and Dental Sciences  Niigata 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