{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:57:34Z","timestamp":1790913454193,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":264,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Survivors of acute kidney injury (AKI) in very low birth weight (VLBW) infants may be at risk of developing chronic kidney disease in the long term. Large cohort studies examining risk factors associated with AKI in VLBW infants are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively investigated the risk factors for the development of AKI by comparing the file records of VLBW infants (&lt;1500\u2009g) born between 2019 and 2022 and admitted to the neonatal intensive care unit with and without AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 218 VLBW infants enrolled, 35 (16%) developed AKI. The AKI group had lower gestational age (25.3 vs. 28.9\u2009weeks) and birth weight (760\u2009g vs. 1060\u2009g) compared to the no AKI group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Longer duration of mechanical ventilation, higher rates of inotrope and vancomycin therapy, patent ductus arteriosus (PDA), grade 2\u20133 necrotizing enterocolitis (NEC), and severe intraventricular hemorrhage (IVH) were more common in the AKI group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In multivariate analysis, gestational age (OR 0.70, 95% CI 0.50\u20130.98,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036) and inotrope use \u22653\u2009days (OR 6.13, 95% CI 2.06\u201318.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) were independently associated with AKI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hypotension is a strong predictor of the development of AKI in VLBW infants in the NICU. Our findings highlight the importance of early identification of high\u2010risk neonates and closer hemodynamic monitoring to prevent AKI in very preterm infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70215","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T12:27:04Z","timestamp":1758544024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Poor hemodynamic profile is associated with acute kidney injury in very low birth weight infants"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5146-6949","authenticated-orcid":false,"given":"Omer","family":"Guran","sequence":"first","affiliation":[{"name":"Department of Neonatology University of Health Sciences, Umraniye Training and Research Hospital  Umraniye, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda Yavanoglu","family":"Atay","sequence":"additional","affiliation":[{"name":"Department of Neonatology University of Health Sciences, Umraniye Training and Research Hospital  Umraniye, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Neonatology University of Health Sciences, Umraniye Training and Research Hospital  Umraniye, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Colak","sequence":"additional","affiliation":[{"name":"Department of Neonatology University of Health Sciences, Umraniye Training and Research Hospital  Umraniye, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilke Mungan","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Neonatology University of Health Sciences, Umraniye Training and Research Hospital  Umraniye, Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-0656-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2016.12.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2022.11.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1133-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-017-0810-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(17)30069-X"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.10.048"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289803700609"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1186-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-012-0371-3"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"69","article-title":"Acute kidney injury in premature, very low\u2010birth\u2010weight infants","volume":"5","author":"Mian AN","year":"2016","journal-title":"J Pediatr Intensive Care"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05190514"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31820b95ca"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1459553"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3400311"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501708"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1722330"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187764"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.0322"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-1060-2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11454"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5713"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32834f62d5"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.136"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"issue":"6","key":"e_1_2_9_29_1","first-page":"470","article-title":"Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. 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