{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:05:16Z","timestamp":1791399916016,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":279,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence supporting the use of musical intervention in the PICU is still limited. This systematic review aims to examine the current literature on musical interventions for sedation, analgesia, and delirium in critically ill children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search was conducted using MEDLINE, PUBMED, Google Scholar, and EMBASE from inception until December 31, 2024, using relevant medical subject headings and specific search terms. The Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) Strategy was followed for article selection. Two reviewers independently screened studies for eligibility. Risk of bias was assessed, and the quality of evidence was evaluated using the GRADE methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven studies were included in the final analysis (1 randomized crossover trial, 3 randomized controlled trials, and 3 pretest\u2010posttest studies). Due to the risk of bias, heterogeneity, and small sample sizes, the overall quality of evidence was rated as low. The review found that musical intervention led to a decline in heart rate in 5 studies, reduced procedural pain in 2 studies, and increased comfort in 4 studies. No improvement in delirium scores was observed in one single\u2010center pilot study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although evidence is limited, musical intervention shows promise as a non\u2010pharmacologic option for sedation and analgesia in critically ill children in the PICU. Further research is needed to explore its effects on pediatric delirium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70222","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:11:50Z","timestamp":1759824710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Musical interventions for comfort Care in Critically ill Children: A systematic review"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4677-4223","authenticated-orcid":false,"given":"Chanapai","family":"Chaiyakulsil","sequence":"first","affiliation":[{"name":"Division of Pediatric Critical Care, Department of Pediatrics Thammasat University Hospital, Faculty of Medicine, Thammasat University  Khlong Nueng Pathumthani Thailand"},{"name":"Center of Excellence in Applied Epidemiology Thammasat University  Khlong Nueng Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawida","family":"Kusolmanomai","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Thammasat University Hospital, Faculty of Medicine, Thammasat University  Khlong Nueng Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1013-4720","authenticated-orcid":false,"given":"Marut","family":"Chantra","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2021.11.002"},{"issue":"2","key":"e_1_2_10_3_1","first-page":"78","article-title":"The role of music to promote relaxation in intensive care unit patients","volume":"8","author":"Mangoulia P","year":"2013","journal-title":"Hospital Chronicles"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5151.94893"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.209858"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/104990910302000211"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000154773.11986.39"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11121687"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebn.7.4.103"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5056-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8760(97)00071-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.15436\/2377-1364.17.061"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp-20-328"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002873"},{"issue":"12","key":"e_1_2_10_15_1","article-title":"Music interventions for mechanically ventilated patients","volume":"2014","author":"Bradt J","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.01.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.5670"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2019.06.006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-4-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_10_21_1","article-title":"ROBINS\u2010I: a tool for assessing risk of bias in non\u2010randomised studies of interventions","volume":"12","author":"Sterne JA","year":"2016","journal-title":"BMJ"},{"key":"e_1_2_10_22_1","unstructured":"Sch\u00fcnemannH Bro\u017cekJ GuyattG OxmanA.GRADE handbook for grading the quality of evidence and the strength of recommendations using the GRADE approach. 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