{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:58:09Z","timestamp":1790913489155,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":328,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early\u2010onset neonatal sepsis (EOS) is defined as an infection with a positive blood culture within the first 7\u2009days of life. The categorical risk assessment guideline from the Centers for Disease Control and Prevention is used to manage high\u2010risk infants, but it often results in a high rate of antibiotic use. A neonatal early\u2010onset sepsis calculator (EOS calculator) was developed to reduce the overuse of antibiotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted among infants born \u226535\u2009weeks' gestation admitted to Vajira Hospital between October 1, 2018, and September 30, 2019. Infants were included if they had at least one risk factor for EOS or symptoms suggesting EOS. Relevant data were collected to assess antibiotic use rates based on the categorical risk assessment and the EOS calculator. Antibiotic use rates between the two methods were compared using the chi\u2010square test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 177 infants were included in this study. The mean gestational age (\u00b1SD) was 38.5\u2009\u00b1\u20091.7\u2009weeks, and the mean birth weight (\u00b1SD) was 2923.9\u2009\u00b1\u2009516.3\u2009g. According to local guidelines, antibiotics were administered to 73 infants (41.2%). One infant had culture\u2010proven EOS, yielding a prevalence among the total live births born at \u226535\u2009weeks' gestation of 0.49 per 1000 live births (1\/2031). No deaths were observed. Antibiotic use rates were 45.2% using the categorical risk assessment and 31.6% using the EOS calculator (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The rate of antibiotic use was lower with the EOS calculator than with the categorical risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70276","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T10:32:49Z","timestamp":1764066769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotic use rate in neonates: A comparison of categorical risk assessment and the sepsis calculator"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3012-9601","authenticated-orcid":false,"given":"Dissajee","family":"Lumbiganon","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Faculty of Medicine Vajira Hospital Navamindradhiraj University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panitnart","family":"Kempunjagul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Vajira Hospital Navamindradhiraj University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00031-13"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2217"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e318223bad2"},{"issue":"10","key":"e_1_2_9_5_1","first-page":"1","article-title":"Prevention of perinatal group B streptococcal disease\u2013revised guidelines from CDC, 2010","volume":"59","author":"Verani JR","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0541"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.11.056"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-2894"},{"issue":"1","key":"e_1_2_9_9_1","first-page":"206","article-title":"Prevention of group B streptococcal early\u2010onset disease in newborns: ACOG Committee opinion summary, number 782","volume":"134","author":"American College of Obstetricians and Gynecologists","year":"2019","journal-title":"Obstet Gynecol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2012.96"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.02.035"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.05.033"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-3464"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1689"},{"key":"e_1_2_9_15_1","unstructured":"Northern California Kaiser\u2010Permanente.Neonatal early\u2010onset sepsis calculator. [Cited 2018 April 5]. Available from:https:\/\/neonatalsepsiscalculator.kaiserpermanente.org\/"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.2825"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15391"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-04993-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2023.04.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.236"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.4.e41"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.35.1.99"},{"key":"e_1_2_9_23_1","first-page":"1063","article-title":"Neonatal group B Streptococcus sepsis: a multicenter study in Thailand","volume":"48","author":"Thatrimontrichai A","year":"2017","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"e_1_2_9_24_1","unstructured":"NgamjarusC ChongsuvivatwongV.n4Studies: Sample size and power calculations for iOS. The Royal Golden Jubilee Ph.D. Program \u2010 The Thailand Research Fund & Prince of Songkla University 2014."},{"key":"e_1_2_9_25_1","first-page":"152","volume-title":"Sample size calculations in clinical research","author":"Chow SC","year":"2003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.014"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001885"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1676829"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000906"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2174-8"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-021-01028-1"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-301767"},{"issue":"4","key":"e_1_2_9_34_1","first-page":"728","article-title":"The burden of invasive neonatal group B streptococcal (GBS) disease in Thailand and The Philippines","volume":"46","author":"Villanueva\u2010Uy ME","year":"2015","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"11","key":"e_1_2_9_35_1","first-page":"1162","article-title":"The prevalence of group B streptococcus (GBS) colonization in pregnant women","volume":"100","author":"Khamching C","year":"2017","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2019.1587597"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix658"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:48:41Z","timestamp":1790912921000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/ped.70276"],"URL":"https:\/\/doi.org\/10.1111\/ped.70276","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70276"}}