{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:31:14Z","timestamp":1773012674868,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The combination of thiopurines and partial enteral nutrition (TP\/PEN) is a common maintenance therapy for mild\u2010to\u2010moderate Crohn's disease (CD) in pediatric patients. However, no studies have investigated the efficacy of TP\/PEN. This study aimed to evaluate the non\u2010relapse and complete mucosal healing rates in pediatric CD patients following treatment with or without TP, in addition to PEN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included 39 pediatric patients diagnosed with mild\u2010to\u2010moderate CD. Based on the proposed treatment, the patients were divided into the TP\/PEN and PEN\u2010only groups. The primary outcome was the relapse\u2010free rate between the two groups. Relapse was defined as a pediatric Crohn's disease activity index (PCDAI) &gt;12.5, Simple Endoscopic Score\u2010CD (SES\u2010CD) score &gt;7, Lewis score\u2009&gt;\u2009135, and\/or abnormal C\u2010reactive protein levels (CRP &gt;\u20090.15\u2009mg\/dL). The secondary outcome was complete mucosal healing (SES\u2010CD score 0) at 12\u201324\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Although the difference in non\u2010relapse rate between the two groups was not statistically significant, complete mucosal healing rates were significantly higher in the TP\/PEN group than in the PEN\u2010only group. Complete mucosal healing at 12\u201324\u2009months was achieved in 7\/21 (33.3%) and 1\/18 (5.5%) patients in the TP\/PEN and PEN\u2010only groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nowadays, more treatment options are available, and TP\/PEN remains a viable option for the treatment of mild\u2010to\u2010moderate CD in pediatric patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70290","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:42:56Z","timestamp":1768405376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combining thiopurine with partial enteral nutrition promotes complete mucosal healing in pediatric Crohn's disease"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-7085","authenticated-orcid":false,"given":"Emiri","family":"Kaji","sequence":"first","affiliation":[{"name":"Department of Pediatrics Osaka Medical and Pharmaceutical University  Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Yoden","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka Medical and Pharmaceutical University  Takatsuki Osaka Japan"},{"name":"Department of Pediatrics Kawanishi City Medical Center  Kawanishi Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Namba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka Medical and Pharmaceutical University  Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka Medical and Pharmaceutical University  Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-3503","authenticated-orcid":false,"given":"Masano","family":"Otani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka Saiseikai Suita Hospital  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7707-293X","authenticated-orcid":false,"given":"Takeru","family":"Okuhira","sequence":"additional","affiliation":[{"name":"Okuhira Nobinobi Children's Clinic  Mishima Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"Inoue Children's Clinic  Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Aomatsu","sequence":"additional","affiliation":[{"name":"Aomatsu Pediatrics Clinic  Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3116-1195","authenticated-orcid":false,"given":"Daisuke","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Research &amp; Development Center Osaka Medical and Pharmaceutical University  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ashida","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka Medical and Pharmaceutical University  Takatsuki Osaka 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