{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:11:40Z","timestamp":1785337900842,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with short bowel syndrome (SBS)\u2010associated intestinal failure (SBS\u2010IF) are dependent on parenteral support (PS). In Japan, teduglutide is the only GLP\u20102 analog medicine indicated for these patients. There are limited data for pediatric patients, especially those with a low body weight. This study evaluated the safety and efficacy of teduglutide in Japanese pediatric patients with SBS\u2010IF (dependence on PS to provide \u226530% of fluid or caloric intake needs) who weighed less than 10\u2009kg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This phase 3, open\u2010label study enrolled Japanese pediatric patients with SBS\u2010IF. Patients weighing less than 10\u2009kg received teduglutide 0.05\u2009mg\/kg\/day subcutaneously in 28\u2010week treatment cycles (24\u2009weeks of teduglutide treatment and 4\u2009weeks of follow\u2010up). Adverse events, changes in PS requirements, and growth parameters were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three patients completed the study, with a mean teduglutide exposure duration of 48.9\u2009weeks. All patients experienced treatment\u2010emergent adverse events (TEAEs), but none were related to the study drug or led to death or treatment discontinuation. Clinically meaningful reductions in mean PS volume (13.1%) and mean PS caloric intake (46.6%) were observed at the end of treatment from baseline. One patient achieved a reduction in PS volume of \u226520% at the end of treatment from baseline. Growth parameters showed increases in weight and height\/length\u2010for\u2010age\n                      <jats:italic>z<\/jats:italic>\n                      \u2010scores at the end of treatment from baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the three patients with SBS\u2010IF who weighed less than 10\u2009kg, no new safety signals were observed following teduglutide treatment. Clinically meaningful reductions in PS were noted and there was no adverse impact on growth parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      registration number: NCT05027308\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70301","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T08:34:27Z","timestamp":1766824467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Teduglutide in pediatric patients under 10\u2009kg with short bowel syndrome on parenteral support: An open\u2010label study"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0312-9403","authenticated-orcid":false,"given":"Kouji","family":"Masumoto","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Institute of Medicine University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3272-0785","authenticated-orcid":false,"given":"Mitsuru","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly Kagoshima University  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8936-932X","authenticated-orcid":false,"given":"Takato","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Institute of Medicine University of Tsukuba  Tsukuba 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