{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:31:12Z","timestamp":1773012672501,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Iron deficiency anemia (IDA) in children poses significant health risks, necessitating effective treatment strategies. While daily oral iron therapy is standard, alternate\u2010day therapy has emerged as a potential alternative to improve compliance and minimize side effects. This study aimed to compare the efficacy of daily and alternate\u2010day iron supplementation in children with IDA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 82 children with nutritional IDA receiving either daily (42 patients) or alternate\u2010day (40 patients) oral ferrous sulfate therapy. Hematologic and iron parameters, including hemoglobin (Hb), ferritin, and total iron\u2010binding capacity (TIBC), were evaluated at baseline, day 10, 1, and 3 months. Statistical analyses were performed using SPSS, with\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05 considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No significant differences in Hb changes were observed based on the treatment regimens. When comparing Hb changes from diagnosis to the first month and from the first month to the third month, a significant increase was noted in the daily therapy group during the first month. At the beginning of the study, the mean corpuscular volume (MCV) values were higher in the alternate\u2010day group, while the red cell distribution width (RDW) values at diagnosis were greater in the daily group. Throughout the first and third months, MCV and RDW values were similar between the two groups. Additionally, ferritin and TIBC levels showed no significant differences over the study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Alternate\u2010day oral iron therapy is as effective as daily therapy in managing pediatric IDA, offering a viable alternative with similar hematologic and iron parameter improvements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70328","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T07:45:52Z","timestamp":1770104752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Daily versus alternate day oral iron treatment for children with nutritional iron deficiency anemia"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7683-668X","authenticated-orcid":false,"given":"Sinan","family":"Sayl\u0131k","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics Necmettin Erbakan University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesile Meltem","family":"Energin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics Necmettin Erbakan University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"B\u00fcy\u00fckavc\u0131","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatric Hematology and Oncology Necmettin Erbakan University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahsen Nur","family":"Sayl\u0131k","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics Necmettin Erbakan University  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"104","article-title":"Anaemia: a disease or symptom?","volume":"78","author":"Newhall DA","year":"2020","journal-title":"Neth J Med"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14092"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32594-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12040289"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c01833"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.03.011"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.116.013961"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-022-2622-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-642223"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02817-7"},{"key":"e_1_2_10_13_1","first-page":"167","article-title":"Is every other day iron therapy an alternative to classical treatment in children? Comparison of early response to the iron treatment","volume":"8","author":"Akcan N","year":"2018","journal-title":"J Behcet Uz Child Hosp"},{"key":"e_1_2_10_14_1","volume-title":"Lanzkowsky's manual of pediatric hematology and oncology","author":"Lanzkowsky P","year":"2016"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.01.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30182-5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14766"},{"key":"e_1_2_10_18_1","first-page":"39","article-title":"A prospective, randomized, interventional study of Oral iron supplementation comparing daily dose with alternate day regimen using hepcidin as a biomarker in iron deficiency anemia","volume":"68","author":"Mehta S","year":"2020","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03871-z"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-04835-6"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-29034-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000034421"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70328","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:14:31Z","timestamp":1773008071000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ped.70328"],"URL":"https:\/\/doi.org\/10.1111\/ped.70328","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70328"}}