{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:31:07Z","timestamp":1773012667067,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulmonary exacerbations (PEs) are associated with a subsequent decline in lung function. We aim to evaluate lung function in cystic fibrosis (CF) patients with frequent PEs in their first 2\u2009years of age using spirometry at age 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included CF patients who were 6\u2009years old from the CF registry of Turkey in 2019. According to the number of PEs, patients were classified: those who had two or fewer PEs in the first 2\u2009years of age were defined as Group 1 and those who had more than two PEs were defined as Group 2. The patients' demographics and clinical characteristics were compared between Group 1 and Group 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 88 patients who had data on PE from their first 2\u2009years and completed their sixth year by 2019. Fifty\u2010nine patients were included in Group 1 and 29 in Group 2. The mean percent\u2010predictive FEV1 (ppFEV1), percent\u2010predictive FVC (ppFVC) values, and the mean age at first PE were lower in Group 2 than in Group 1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The patients with chronic\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (PA) colonization had lower mean ppFEV1 and ppFVC values than those without (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). Patients with PA in respiratory\u2010sample culture during their first PE had lower ppFEV1 and ppFVC values than those with SA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046; 0.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study showed that more frequent PEs in the first 2\u2009years of age and chronic PA colonization were associated with poorer FEV1, FVC, and BMI values in CF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70345","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T12:50:14Z","timestamp":1770641414000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lung function outcomes of cystic fibrosis patients after early\u2010life pulmonary exacerbations: National registry analysis"],"prefix":"10.1111","volume":"68","author":[{"given":"Sat\u0131","family":"\u00d6zkan Tabak\u00e7\u0131","sequence":"first","affiliation":[{"name":"Department of Pediatric Pulmonology Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salih","family":"Uytun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2309-7952","authenticated-orcid":false,"given":"Sanem","family":"Ery\u0131lmaz Polat","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Ankara City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fczin","family":"Cinel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology Ankara City Hospital  Ankara Turkey"},{"name":"Department of Pediatric Pulmonology, Faculty of Medicine Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nural","family":"Kiper","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem","family":"Akg\u00fcl Erdal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Faculty of Medicine Hacettepe University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velat","family":"\u015een","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Faculty of Medicine Dicle University  Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suat","family":"Sava\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Dicle University  Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zcan","family":"\u00c7elebi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Dicle University  Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derya","family":"Ufuk Alt\u0131nta\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology, Faculty of Medicine \u00c7ukurova University  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahir","family":"Serbes","sequence":"additional","affiliation":[{"name":"Department of Pediatric Allergy and Immunology, Faculty of Medicine \u00c7ukurova University  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"Ayz\u0131t K\u0131l\u0131n\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Cerrahpa\u015fa Faculty of Medicine \u0130stanbul University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haluk","family":"\u00c7oku\u011fra\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Cerrahpa\u015fa Faculty of Medicine \u0130stanbul University  \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pulmonology, Cerrahpa\u015fa Faculty of Medicine \u0130stanbul University  \u0130stanbul 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