{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:07:06Z","timestamp":1774526826276,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":84,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Food protein\u2013induced enterocolitis syndrome (FPIES) is a non\u2010IgE\u2010mediated gastrointestinal food allergy characterized by delayed\u2010onset vomiting. Although ondansetron has demonstrated efficacy in managing FPIES\u2010related symptoms, its use remains off\u2010label in Japan. Granisetron hydrochloride (GH), another 5\u2010HT\n                      <jats:sub>3<\/jats:sub>\n                      receptor antagonist, is approved in Japan for postoperative and chemotherapy\u2010induced nausea and vomiting in children and is widely used in pediatric clinical settings. However, its use in FPIES has not been fully evaluated. This study aimed to assess the effectiveness and safety of intravenous GH in Japanese children undergoing oral food challenges (OFCs) for FPIES.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included pediatric patients who underwent OFCs for suspected or confirmed FPIES between January 2019 and September 2024 at a single center in Japan. Patients who developed vomiting received intravenous GH (40\u2009\u03bcg\/kg) and were subsequently monitored for symptom resolution, recurrence, the need for additional interventions, and any adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 73 OFCs performed in 50 patients, 20 (27.4%) yielded a positive result, defined by the occurrence of vomiting. Of these, 18 cases from 16 patients received intravenous GH, and 16 OFCs from 14 patients were included in the final analysis. Vomiting resolved completely in 12 cases (75.0%), while four (25.0%) experienced only one additional vomiting episode. No cases required further antiemetic therapy or fluid resuscitation, and no GH\u2010related adverse events were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intravenous GH was well\u2010tolerated and may be effective in managing vomiting associated with FPIES during OFCs. These findings suggest that GH may be a practical therapeutic option, warranting further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70368","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:06:29Z","timestamp":1774523189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intravenous granisetron for food protein\u2013induced enterocolitis syndrome in Japanese children: A retrospective study"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-5296","authenticated-orcid":false,"given":"Doi","family":"Masaaki","sequence":"first","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"},{"name":"Department of Pediatrics Minaminara General Medical Center  Oyodo\u2010cho, Yoshino\u2010gun Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwakoshi","family":"Nayu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nogami","family":"Takuya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yano","family":"Ryuuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nakayama","family":"Ryunosuke","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandai","family":"Tsuyoshi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinguryo","family":"Daiki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsujimoto","family":"Rikiho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujino","family":"Maho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanagino","family":"Satoshi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshida","family":"Ryouta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimura","family":"Yoshiko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furuichi","family":"Yasuko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Higashiosaka City Medical Center  Higashiosaka Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.alit.2024.01.006","article-title":"Current and future perspectives on the consensus guideline for food protein\u2010induced enterocolitis syndrome (FPIES)","volume":"73","author":"Anvari S","year":"2024","journal-title":"Allergol Int"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.jaci.2016.12.966","article-title":"International consensus guidelines for the diagnosis and management of food protein\u2010induced enterocolitis syndrome:executive summary\u2010workgroup report of the adverse reactions to foods committee, American Academy of Allergy, Asthma & Immunology","volume":"139","author":"Nowak\u2010W\u0119grzyn A","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.jaip.2020.01.030","article-title":"A slice of food protein\u2010induced Enterocolitis syndrome (FPIES): insights from 441 children with FPIES as provided by caregivers in the international FPIES association","volume":"8","author":"Maciag MC","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"5","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.jaci.2013.06.021","article-title":"Use of ondansetron for food protein\u2010induced enterocolitis syndrome","volume":"132","author":"Holbrook T","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/all.13033","article-title":"Ondansetron in acute food protein\u2010induced enterocolitis syndrome, a retrospective case\u2010control study","volume":"72","author":"Miceli Sopo S","year":"2017","journal-title":"Allergy"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000363384","article-title":"Ondansetron for food protein\u2010induced enterocolitis syndrome","volume":"164","author":"Miceli Sopo S","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.anai.2021.01.020","article-title":"Management of acute food protein\u2010induced enterocolitis syndrome emergencies at home and in a medical facility","volume":"126","author":"Leonard SA","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000227054","article-title":"Mechanism of the anti\u2010emetic activity of 5\u2010HT3 receptor antagonists","volume":"49","author":"Tyers MB","year":"1992","journal-title":"Oncology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1056\/NEJMra0706547","article-title":"Chemotherapy\u2010induced nausea and vomiting","volume":"358","author":"Hesketh PJ","year":"2008","journal-title":"N Engl J Med"},{"key":"e_1_2_11_11_1","article-title":"Granisetron for food protein\u2010induced enterocolitis syndrome: efficacy and safety evaluation (in Japanese)","volume":"71","author":"Iwakoshi N","year":"2022","journal-title":"Jpn J Allergol"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5415\/apallergy.0000000000000185","article-title":"Treatments for gastrointestinal symptoms in acute food protein\u2010induced enterocolitis syndrome","volume":"15","author":"Hamada M","year":"2025","journal-title":"Asia Pac Allergy"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","DOI":"10.3390\/ph17050616","article-title":"Anti\u2010emetics in children receiving chemotherapy for solid tumors and leukemia: pharmacology and optimization of therapy for nausea and vomiting","volume":"17","author":"Ganguly S","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.5152\/TJAR.2019.67503","article-title":"Postoperative nausea and vomiting in paediatric anaesthesia","volume":"48","author":"Urits I","year":"2020","journal-title":"Turk J Anaesthesiol Reanim"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.5649\/jjphcs.33.424","article-title":"Survey of serotonin receptor antagonist usage at National Cancer Center Hospital","volume":"33","author":"Yanai T","year":"2007","journal-title":"Jpn J Pharm Health Care Sci"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF02347270","article-title":"A controlled, dose\u2010comparison study of granisetron for nausea and vomiting induced by cancer chemotherapy in children","volume":"1","author":"Fujimoto T","year":"1996","journal-title":"Int J Clin Oncol"},{"key":"e_1_2_11_17_1","first-page":"673","article-title":"Effects of granisetron in children undergoing high\u2010dose chemotherapy: a multi\u2010institutional, cross\u2010over study","volume":"14","author":"Tsuchida Y","year":"1999","journal-title":"Int J Oncol"},{"key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0959-8049(99)00071-4","article-title":"A randomised dose\u2010comparison trial of granisetron in preventing emesis in children with leukaemia receiving emetogenic chemotherapy","volume":"35","author":"Komada Y","year":"1999","journal-title":"Eur J Cancer"},{"key":"e_1_2_11_19_1","unstructured":"Granisetron Hydrochloride [package insert]. Tokyo Japan: Neocriticare Pharmaceutical Co. Ltd; revised July 2022."},{"key":"e_1_2_11_20_1","first-page":"21","article-title":"Studies on the storage of hen's eggs (part I): specific gravity, proportion of each part, changes in albumen, yolk index, and pH","volume":"6","author":"Inoue F","year":"1966","journal-title":"J Teikyo Junior Coll"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1080\/17425255.2017.1396317","article-title":"Granisetron: a review of pharmacokinetics and clinical experience in chemotherapy induced \u2013 nausea and vomiting","volume":"13","author":"Spartinou A","year":"2017","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"e_1_2_11_22_1","volume-title":"Antiemetics, Selective 5\u2010HT3 Antagonists. StatPearls [Internet]","author":"Theriot J","year":"2024"},{"key":"e_1_2_11_23_1","unstructured":"Granisetron Hydrochloride [package insert]. Tokyo Japan: Meiji Seika Pharma Co. Ltd; revised August 2022."},{"key":"e_1_2_11_24_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13223-022-00694-y","article-title":"Food protein\u2010induced enterocolitis syndrome in a tertiary pediatric center: safety of guideline\u2010conforming food challenges","volume":"18","author":"Wong S","year":"2022","journal-title":"Allergy Asthma Clin Immunol"},{"key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/ACI.0000000000000053","article-title":"Natural history of food protein\u2010induced enterocolitis syndrome","volume":"14","author":"Katz Y","year":"2014","journal-title":"Curr Opin Allergy Clin Immunol"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T11:06:33Z","timestamp":1774523193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ped.70368"],"URL":"https:\/\/doi.org\/10.1111\/ped.70368","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70368"}}