{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:35:56Z","timestamp":1774877756863,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":88,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Meconium\u2010related ileus (MRI) is a common gastrointestinal complication in extremely low birthweight infants (ELBWIs) that may delay enteral nutrition and adversely affect growth and neurodevelopment. This study aimed to determine the incidence of MRI in ELBWIs, identify associated clinical factors, and investigate short\u2010 and long\u2010term impacts on growth and neurodevelopment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed medical records of ELBWIs admitted to a single neonatal intensive care unit between January 2015 and August 2021. We investigated the prevalence of MRI and examined clinical features associated with MRI development by comparing patients with and without MRI. Additionally, we compared growth and neurodevelopmental outcomes among infants who completed at least 3\u2009years of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 108 ELBWIs, MRI was observed in 24 (22%) patients. Four patients developed intestinal perforation, resulting in two deaths. The other 20 cases (87%) were resolved with Gastrografin enema. Patients from twin pregnancies developed MRI more frequently than those from single pregnancies (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). MRI patients had significantly longer time to establish enteral nutrition (21.5\u2009days vs. 12\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). No significant differences were observed in height or weight at corrected ages of 6, 12, 24, and 36\u2009months between patients with and without MRI. There was no statistically significant difference in neurodevelopmental impairment rates at age 3\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While MRI was associated with delayed establishment of enteral nutrition, it did not demonstrate short\u2010 or long\u2010term adverse effects on growth or neurodevelopment in ELBWIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70380","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:44:27Z","timestamp":1774874667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Meconium\u2010related ileus in extremely low birthweight infants: Growth and neurodevelopmental outcomes"],"prefix":"10.1111","volume":"68","author":[{"given":"Shogo","family":"Zuo","sequence":"first","affiliation":[{"name":"Department of Surgery Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Surgery Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Kanehiro","sequence":"additional","affiliation":[{"name":"Department of Surgery Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Kamamoto","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care, Maternal, Fetal and Neonatal Medical Center Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Tonegawa","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care, Maternal, Fetal and Neonatal Medical Center Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Tani","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care, Maternal, Fetal and Neonatal Medical Center Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-0540","authenticated-orcid":false,"given":"Eri","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care, Maternal, Fetal and Neonatal Medical Center Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirosato","family":"Aoki","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care, Maternal, Fetal and Neonatal Medical Center Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Uchida","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care, Maternal, Fetal and Neonatal Medical Center Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6208-7661","authenticated-orcid":false,"given":"Masayuki","family":"Sho","sequence":"additional","affiliation":[{"name":"Department of Surgery Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1055\/s-2008-1072290","article-title":"Functional ileum in neonates: Hirschsprung's disease\u2010allied disorders versus meconium related ileus","volume":"9","author":"Kubota A","year":"1999","journal-title":"Eur J Pediatr 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