{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:49:47Z","timestamp":1776847787678,"version":"3.51.2"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n This study aimed to evaluate the correlation between arterial and venous blood gas parameters in critically ill pediatric patients and to assess their association with prognostic indicators and clinical outcomes. The feasibility of using venous blood gas analysis as a less invasive alternative to arterial sampling was also explored.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A prospective observational study was conducted in the PICU. Simultaneous arterial and venous blood gas samples were collected on the first and second days of admission. Associations with PRISM and PELOD, mortality, and the need for critical care interventions were investigated using correlation analyses and ROC curves.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 104 patients, arterial and venous pH, pCO\n 2<\/jats:sub>\n , HCO\n 3<\/jats:sub>\n , and base excess showed strong correlations (\n r<\/jats:italic>\n \u2009>\u20090.8), while lactate levels showed moderate agreement. Venous PCO\n 2<\/jats:sub>\n and lactate were significantly higher in nonsurvivors and correlated with PRISM and PELOD scores. On both days, lactate levels and venous PCO\n 2<\/jats:sub>\n were predictive of mortality (AUCs: 0.660\u20130.744). The Pv\u2013aCO\n 2<\/jats:sub>\n difference was significantly elevated in nonsurvivors on the first day. Oxygenation parameters (SpO\n 2<\/jats:sub>\n , PaO\n 2<\/jats:sub>\n , O\n 2<\/jats:sub>\n Hb) showed weak correlation, indicating the continued need for arterial sampling in hypoxemic conditions.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Venous blood gas analysis reliably reflects acid\u2013base status and may be an alternative to arterial sampling for selected parameters in critically ill pediatric patients. Venous PCO\n 2<\/jats:sub>\n , lactate levels, and Pv\u2013aCO\n 2<\/jats:sub>\n may be useful for risk stratification and longitudinal monitoring in the PICU. However, arterial analysis remains essential for oxygenation, and venous sampling should not substitute arterial measurements when evaluating hypoxemia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ped.70383","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:51:47Z","timestamp":1776844307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arterial\u2013venous blood gas correlation and prognostic significance in critically ill pediatric patients"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-9223","authenticated-orcid":false,"given":"Ilayda","family":"Altun","sequence":"first","affiliation":[{"name":"Cerrahpasa Medical Faculty Istanbul University Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-7155","authenticated-orcid":false,"given":"Fatma Deniz","family":"Ayg\u00fcn","sequence":"additional","affiliation":[{"name":"Cerrahpasa Medical Faculty Istanbul University Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6519-6583","authenticated-orcid":false,"given":"Fatih","family":"Ayg\u00fcn","sequence":"additional","affiliation":[{"name":"Cerrahpasa Medical Faculty Istanbul University Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.7326\/0003-4819-105-3-390","article-title":"DIAGNOSIS AND TREATMENT diagnostic decision indications for arterial blood gas analysis","volume":"105","author":"Raffin TA","year":"1986","journal-title":"Ann Intern Med"},{"issue":"6","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.5005\/jp-journals-10071-23176","article-title":"Central venous blood gas analysis: an alternative to arterial blood gas analysis for ph, PCO2, bicarbonate, sodium, potassium and chloride in the intensive care unit patients","volume":"23","author":"Bijapur MB","year":"2019","journal-title":"Indian J Crit Care Med"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2147\/OAEM.S228420","article-title":"Can venous blood gas be used as an alternative to arterial blood gas in intubated patients at admission to the emergency department? 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