{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:20:58Z","timestamp":1776259258878,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":104,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>We report an extremely low birth weight infant with gastroesophageal reflux disease who developed persistent hypokalemia and metabolic alkalosis after treatment with rikkunshito. These findings gradually resolved after discontinuation of rikkunshito and potassium supplementation, suggesting licorice\u2010induced pseudoaldosteronism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70407","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T12:26:58Z","timestamp":1776256018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Licorice\u2010Induced Pseudoaldosteronism Caused by Rikkunshito in an Extremely Low Birth Weight Infant"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7338-6133","authenticated-orcid":false,"given":"Toshihiro","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3064-5808","authenticated-orcid":false,"given":"Naofumi","family":"Hanyu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0083-059X","authenticated-orcid":false,"given":"Shonosuke","family":"Nara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4644-3136","authenticated-orcid":false,"given":"Takashi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-7187","authenticated-orcid":false,"given":"Gaku","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/ped.12582","article-title":"Efficacy of the Japanese Herbal Medicine Rikkunshito in Infants With Gastroesophageal Reflux Disease","volume":"57","author":"Otake K.","year":"2015","journal-title":"Pediatrics International"},{"issue":"7","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133159","article-title":"Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived From Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross\u2010Over, Randomized Study","volume":"10","author":"Kitagawa H.","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.719197","article-title":"Clinical Risk Factors of Licorice\u2010Induced Pseudoaldosteronism Based on Glycyrrhizin\u2010Metabolite Concentrations: A Narrative Review","volume":"17","author":"Yoshino T.","year":"2021","journal-title":"Frontiers in Nutrition"},{"issue":"8","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1124\/dmd.119.086462","article-title":"Ontogeny of Hepatic Sulfotransferases and Prediction of Age\u2010Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism","volume":"47","author":"Ladumor M. K.","year":"2019","journal-title":"Drug Metabolism and Disposition"},{"issue":"1","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1042\/bj1960257","article-title":"The Prenatal and Postnatal Development of UDP\u2010Glucuronyltransferase Activity Towards Bilirubin and the Effect of Premature Birth on This Activity in the Human Liver","volume":"196","author":"Kawade N.","year":"1981","journal-title":"Biochemical Journal"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T12:26:59Z","timestamp":1776256019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ped.70407"],"URL":"https:\/\/doi.org\/10.1111\/ped.70407","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70407"}}