{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:04:27Z","timestamp":1789524267485,"version":"build-2803163510"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1111\/ped.70415","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:19:57Z","timestamp":1779779997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Denosumab in Aggressive Benign Bone Lesions in Children"],"prefix":"10.1111","volume":"68","author":[{"given":"Tatiana","family":"Moreira","sequence":"first","affiliation":[{"name":"Department of Pediatrics S\u00e3o Jo\u00e3o Local Health Unit  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00e9","family":"Cavaleiro","sequence":"additional","affiliation":[{"name":"Department of Stomatology S\u00e3o Jo\u00e3o Local Health Unit  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology S\u00e3o Jo\u00e3o Local Health Unit  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology S\u00e3o Jo\u00e3o Local Health Unit  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Orthopedics S\u00e3o Jo\u00e3o Local Health Unit  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Rodrigues","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery S\u00e3o Jo\u00e3o Local Health Unit  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"do Bom\u2010Sucesso","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology S\u00e3o Jo\u00e3o Local Health Unit  Porto Portugal"},{"name":"Faculty of Medicine University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.21037\/tp-22-276","article-title":"Denosumab in Pediatric Bone Disorders and the Role of RANKL Blockade: A Narrative Review","volume":"12","author":"Wang D.","year":"2023","journal-title":"Translational Pediatrics"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.580605","article-title":"Denosumab in Giant Cell Tumor of Bone: Current Status and Pitfalls","volume":"10","author":"Li H.","year":"2020","journal-title":"Frontiers in Oncology"},{"key":"e_1_2_8_4_1","unstructured":"European Medicines Agency \u201cXgeva: EPAR \u2013 Product Information \u201dEMA (2025)."},{"issue":"5","key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1210\/clinem\/dgad657","article-title":"Management of RANKL\u2010Mediated Disorders With Denosumab in Children and Adolescents: A Global Expert Guidance Document","volume":"109","author":"Vanderniet J. A.","year":"2024","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"4","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s11914-017-0380-1","article-title":"Denosumab: An Emerging Therapy in Pediatric Bone Disorders","volume":"15","author":"Boyce A. M.","year":"2017","journal-title":"Current Osteoporosis Reports"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70415","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:20:01Z","timestamp":1779780001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ped.70415"],"URL":"https:\/\/doi.org\/10.1111\/ped.70415","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70415"}}