{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:00:38Z","timestamp":1780984838474,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":158,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bowel preparation for pediatric colonoscopy is challenging owing to poor tolerance of high\u2010volume polyethylene glycol (PEG). We investigated bowel preparation quality using reduced\u2010volume PEG and the clinical utility of rescue enemas for incomplete PEG ingestion in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 158 patients (\u2264\u200915\u2009years) undergoing colonoscopy after oral PEG preparation (2014\u20132025). Demographics, PEG volume, vomiting, taste intolerance, and enema use were analyzed. Bowel cleanliness was assessed using the Boston (BBPS) and Ottawa Bowel Preparation Scales (OBPS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age was 13.0\u2009years and median body weight was 42.1\u2009kg. The median PEG dose was 37.9\u2009mL\/kg (below standard recommendations). The cleansing adequacy rate (BBPS \u2265\u20096) was 98.1% (median BBPS: 9.0; OBPS: 0.0). Vomiting and taste intolerance occurred in 11.4% and 42.4% of patients, respectively. Rescue enemas, required in 48.7% of patients, safely maintained adequate cleansing despite incomplete PEG ingestion. Younger age (odds ratio [OR]: 0.84; 95% CI: 0.73\u20130.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022) and taste intolerance (OR: 4.14; 95% CI: 1.34\u201312.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) were significantly associated with vomiting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low\u2010volume PEG was associated with adequate bowel cleansing. Rescue enemas are practical adjuncts for incomplete PEG intake. Because younger age and taste intolerance increase vomiting risk, optimizing PEG tolerability and incorporating rescue measures are essential for pediatric bowel preparation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70421","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:35:05Z","timestamp":1780983305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bowel Preparation Outcomes Using Low\u2010Volume Polyethylene Glycol With Selective Rescue Enema in Pediatric Colonoscopy"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7353-5609","authenticated-orcid":false,"given":"Tomohiro","family":"Ida","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"},{"name":"Hayabusa Internal Medicine Home Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Fukuzawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumito","family":"Yamanishi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Ichimiya","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Nemoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-4877","authenticated-orcid":false,"given":"Takahiro","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Madarame","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Morise","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2902-675X","authenticated-orcid":false,"given":"Shin","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7533-1061","authenticated-orcid":false,"given":"Sakiko","family":"Naito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Nishimata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Itoi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/MPG.0b013e31826630fc","article-title":"Prospective Evaluation of 1\u2010Day Polyethylene Glycol\u20103350 Bowel Preparation Regimen in Children","volume":"56","author":"Abbas M. I.","year":"2013","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1186\/1756-0500-7-648","article-title":"1\u2010Day Bowel Preparation With Polyethylene Glycol 3350 Is as Effective and Safe as a 3\u2010Day Preparation for Colonoscopy in Children","volume":"7","author":"Sorser S. A.","year":"2014","journal-title":"BMC Research Notes"},{"issue":"2","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/MPG.0b013e3182758c69","article-title":"Tolerability, Safety, and Efficacy of PEG 3350 as a 1\u2010Day Bowel Preparation in Children","volume":"56","author":"Walia R.","year":"2013","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"3","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.5152\/tjg.2015.6837","article-title":"Comparison of One and Two\u2010Day Bowel Preparation With Polyethylene Glycol in Pediatric Colonoscopy","volume":"26","author":"Najafi M.","year":"2015","journal-title":"Turkish Journal of Gastroenterology"},{"issue":"1","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41390-020-01216-5","article-title":"Randomized Clinical Trial: Efficacy and Tolerability of Two Different Split Dose of Low\u2010Volume Polyethylene Glycol Electrolytes for Bowel Preparation Before Colonoscopy in Hospitalized Children","volume":"90","author":"Fang S.","year":"2021","journal-title":"Pediatric Research"},{"issue":"4","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000497819","article-title":"Bowel Preparation for Colonoscopy in Children: 1 Day PEG\u20103350 With Bisacodyl Versus 3 Day Sennosides","volume":"37","author":"Tutar E.","year":"2019","journal-title":"Digestive Diseases"},{"issue":"40","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"6260","DOI":"10.3748\/wjg.v26.i40.6260","article-title":"Pediatric Bowel Preparation: Sodium Picosulfate, Magnesium Oxide, Citric Acid vs Polyethylene Glycol, a Randomized Trial","volume":"26","author":"Cuffari C.","year":"2020","journal-title":"World Journal of Gastroenterology"},{"issue":"5","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.21037\/apm-20-582","article-title":"Single Versus Split Dose Polyethylene Glycol for Bowel Preparation in Children Undergoing Colonoscopy: A Systematic Review and Meta\u2010Analysis","volume":"9","author":"Cao J.","year":"2020","journal-title":"Annals of Palliative Medicine"},{"issue":"3","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.gie.2008.05.057","article-title":"The Boston Bowel Preparation Scale: A Valid and Reliable Instrument for Colonoscopy\u2010Oriented Research","volume":"69","author":"Lai E. J.","year":"2009","journal-title":"Gastrointestinal Endoscopy"},{"issue":"4","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0016-5107(03)02875-X","article-title":"Validation of a New Scale for the Assessment of Bowel Preparation Quality","volume":"59","author":"Rostom A.","year":"2004","journal-title":"Gastrointestinal Endoscopy"},{"key":"e_1_2_11_12_1","first-page":"16","volume-title":"Clinical Guidelines for Pediatric Gastrointestinal Endoscopy","author":"Japan Pediatric Endoscopy Society","year":"2017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3230654","article-title":"Effectiveness, Tolerability, and Safety of Different 1\u2010Day Bowel Preparation Regimens for Pediatric Colonoscopy","volume":"2019","author":"Szaflarska\u2010Pop\u0142awska A.","year":"2019","journal-title":"Gastroenterology Research and Practice"},{"issue":"1","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjpo-2017-000118","article-title":"Bowel Preparation for Elective Procedures in Children: A Systematic Review and Meta\u2010Analysis","volume":"1","author":"Gordon M.","year":"2017","journal-title":"BMJ Paediatrics Open"},{"issue":"3","key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/MPG.0000000000000978","article-title":"Polyethylene Glycol\u2010 or Sodium Picosulphate\u2010Based Laxatives Before Colonoscopy in Children","volume":"62","author":"Vejzovic V.","year":"2016","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"19","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.3390\/jcm11195747","article-title":"Utility of Diagnostic Colonoscopy in Pediatric Intestinal Disease","volume":"11","author":"Morita M.","year":"2022","journal-title":"Journal of Clinical Medicine"},{"issue":"31","key":"e_1_2_11_17_1","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.3748\/wjg.v23.i31.5773","article-title":"Study to Determine Guidelines for Pediatric Colonoscopy","volume":"23","author":"Yoshioka S.","year":"2017","journal-title":"World Journal of Gastroenterology"},{"issue":"2","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"e366","DOI":"10.1542\/peds.2014-0131","article-title":"Bowel Preparations for Colonoscopy: An RCT","volume":"134","author":"Di Nardo G.","year":"2014","journal-title":"Pediatrics"},{"issue":"2","key":"e_1_2_11_19_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/den.12756","article-title":"Feasibility and Safety of Bowel Cleansing Using Low\u2010Volume Polyethylene Glycol With Ascorbic Acid Before Pediatric Colonoscopy: A Pilot Study","volume":"29","author":"Tsunoda T.","year":"2017","journal-title":"Digestive Endoscopy"},{"issue":"2","key":"e_1_2_11_20_1","first-page":"125","article-title":"Efficacy and Safety of Polyethylene Glycol Electrolyte Solution With Ascorbic Acid for Achieving Good Bowel Preparation Prior to Lower Gastrointestinal Endoscopy in Children","volume":"60","author":"Kakuta F.","year":"2018","journal-title":"Gastroenterological Endoscopy"},{"issue":"1","key":"e_1_2_11_21_1","first-page":"1","article-title":"Efficacy and Safety of Sodium Picosulfate\/Magnesium Citrate Administration for Bowel Cleansing Before Colonoscopy in Children","volume":"37","author":"Hagiwara S.","year":"2023","journal-title":"Japanese Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"1","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12876-018-0895-7","article-title":"One\u2010Day Oral Polyethylene Glycol Based Cleanout Is Effective for Pre\u2010Colonoscopy Preparation in Children","volume":"18","author":"Kumar A. S.","year":"2018","journal-title":"BMC Gastroenterology"},{"issue":"1","key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/MPG.0000000000002511","article-title":"Efficacy of Single\u2010 Versus Split\u2010Dose Polyethylene Glycol for Colonic Preparation in Children: A Randomized Control Study","volume":"70","author":"Tripathi P. R.","year":"2020","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"12","key":"e_1_2_11_24_1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s13312-021-2391-3","article-title":"Efficacy of Two Regimens for Colon Cleansing Using Polyethylene Glycol 4000: A Randomized Open\u2010Label Trial","volume":"58","author":"Hien P. T.","year":"2021","journal-title":"Indian Pediatrics"},{"issue":"5","key":"e_1_2_11_25_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/MPG.0000000000003745","article-title":"Phase III Randomized Non\u2010Inferiority Study of OSS Versus PEG + Electrolyte Colonoscopy Preparation in Adolescents","volume":"76","author":"Socha P.","year":"2023","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"4","key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"E629","DOI":"10.1055\/a-2251-3372","article-title":"Efficacy and Safety of a New Low\u2010Volume PEG With Citrate and Simethicone Bowel Preparation for Pediatric Elective Colonoscopy: Phase 3 RCT","volume":"12","author":"Russo G.","year":"2024","journal-title":"Endoscopy International Open"},{"issue":"1","key":"e_1_2_11_27_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/MPG.0000000000001072","article-title":"Safety of a 1\u2010Day Polyethylene Glycol 3350 Bowel Preparation for Colonoscopy in Children","volume":"63","author":"Sahn B.","year":"2016","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70421","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70421","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:35:10Z","timestamp":1780983310000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ped.70421"],"URL":"https:\/\/doi.org\/10.1111\/ped.70421","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70421"}}