{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:04:30Z","timestamp":1779782670221,"version":"3.53.1"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":145,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV) bronchiolitis is a common cause of respiratory failure requiring pediatric intensive care unit (PICU) admission in young children. Predicting the need for mechanical ventilation remains challenging. We evaluated the usefulness of bronchiolitis severity scores for predicting mechanical ventilation after PICU admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010center retrospective study of children with RSV bronchiolitis admitted to our PICU between April 2021 and July 2023. Inclusion criteria were age &lt;\u200924\u2009months, no underlying respiratory disease, and no prior positive\u2010pressure ventilation. Three bronchiolitis severity scores were retrospectively applied: Modified Wood's Clinical Asthma Score (M\u2010WCAS), Bronchiolitis Score of Sant Joan de D\u00e9u (BROSJOD), and Pediatric Emergency Research Network (PERN) score. Predictive performance for subsequent mechanical ventilation was assessed using the area under the receiver operating characteristic curve (AUC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010one children met the inclusion criteria, and 5 required mechanical ventilation. The median time to mechanical ventilation was 362\u2009min. For predicting mechanical ventilation, BROSJOD (cutoff \u2265\u200912) showed sensitivity 1.000, specificity 0.731, and AUC 0.912; M\u2010WCAS (cutoff \u2265\u20094.5) showed sensitivity 0.800, specificity 0.615, and AUC 0.685; and PERN (cutoff \u2265\u200910) showed sensitivity 1.000, specificity 0.577, and AUC 0.827. DeLong test with Bonferroni correction showed no significant differences among the three scores, although the study was underpowered (estimated power \u2264\u200927%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These bronchiolitis severity scores may help identify the need for mechanical ventilation without delaying intervention. No score was clearly superior, and larger prospective studies are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70429","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:34:22Z","timestamp":1779780862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bronchiolitis Severity Scores for Predicting Mechanical Ventilation Needs in Children With Respiratory Syncytial Virus"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2898-1521","authenticated-orcid":false,"given":"Ayu Ogura","family":"Kawakami","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hyogo Prefectural Amagasaki General Medical Center  Amagasaki Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9921-6842","authenticated-orcid":false,"given":"Koji","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency and Critical Care Medicine Hyogo Prefectural Amagasaki General Medical Center  Amagasaki Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency and Critical Care Medicine Hyogo Prefectural Amagasaki General Medical Center  Amagasaki Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/S0140-6736(22)00478-0","article-title":"Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections due to Respiratory Syncytial Virus in Children Younger Than 5\u2009Years in 2019: A Systematic Analysis","volume":"399","author":"Li Y.","year":"2022","journal-title":"Lancet"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.emc.2011.10.009","article-title":"Common Pediatric Respiratory Emergencies","volume":"30","author":"Choi J.","year":"2012","journal-title":"Emergency Medicine Clinics of North America"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s00431-023-04840-5","article-title":"Comparison of Severity Scales for Acute Bronchiolitis in Real Clinical Practice","volume":"182","author":"Granda E.","year":"2023","journal-title":"European Journal of Pediatrics"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/ppul.23546","article-title":"Bronchiolitis Score of Sant Joan de D\u00e9u: BROSJOD Score, Validation and Usefulness","volume":"52","author":"Balaguer M.","year":"2017","journal-title":"Pediatric Pulmonology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.3109\/02770903.2013.834504","article-title":"Validation of a Scale to Assess the Severity of Bronchiolitis in a Population of Hospitalized Infants","volume":"50","author":"Duarte\u2010Dorado D. M.","year":"2013","journal-title":"Journal of Asthma"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-4253","article-title":"Pediatric Emergency Research Networks (PERN). Predicting Escalated Care in Infants With Bronchiolitis","volume":"142","author":"Freire G.","year":"2018","journal-title":"Pediatrics"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","unstructured":"J.Kim \u201cezr: Easy Use of R via Shiny App for Basic Analyses of Experimental Data. R Package Version 0.1.4 \u201d(2020) https:\/\/github.com\/jinkim3\/ezr.","DOI":"10.32614\/CRAN.package.ezr"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8020066"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:34:25Z","timestamp":1779780865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ped.70429"],"URL":"https:\/\/doi.org\/10.1111\/ped.70429","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70429"}}