{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:49:29Z","timestamp":1782100169597,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":171,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Cystic fibrosis (CF) is a genetic disease in which oxidative stress, chronic inflammation, and autonomic imbalance drive the pathophysiology; however, their interplay in children and adolescents with CF remains unclear. This study aimed to compare the cardiometabolic profile of children and adolescents with CF and healthy controls, and to investigate associations between heart rate variability (HRV), Forced Expiratory Volume in the first second (FEV\n 1<\/jats:sub>\n ), oxidative stress, and inflammation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This cross\u2010sectional study included 12 patients with CF and 12 healthy controls (5\u201318\u2009years). Were analyzed for oxidative stress markers (total antioxidant capacity\u2010CAOx, malondialdehyde\u2010MDA), and inflammatory (hs\u2010CRP, IL\u20102, IL\u20104, IL\u20106, IL\u201010, IL\u201017A, IFN\u2010\u03b3, and TNF\u2010\u03b1). HRV was assessed using a Bluetooth heart rate monitor.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean age was similar between groups (CF: 11.7\u2009\u00b1\u20094.5\u2009years vs. CONT: 12.5\u2009\u00b1\u20094.2\u2009years,\n p<\/jats:italic>\n \u2009=\u20090.68). Mean FEV\n 1<\/jats:sub>\n in the CF group was 78.7%. CF group, MDA was significantly elevated (CF: 3.8\u2009\u00b1\u20091.4\u2009\u03bcM vs. CONT: 2.8\u2009\u00b1\u20090.3\u2009\u03bcM,\n p<\/jats:italic>\n \u2009=\u20090.03), while CAOx was lower (CF: 33.0%\u2009\u00b1\u20094.3% vs. CONT: 45.3%\u2009\u00b1\u200913.6%,\n p<\/jats:italic>\n \u2009=\u20090.01); CRP (CF: 4.6\u2009\u00b1\u20095.67\u2009mg\/L vs. CONT: 0.6\u2009\u00b1\u20090.7\u2009mg\/L,\n p<\/jats:italic>\n \u2009=\u20090.03), IL\u20106 (CF: 53.0\u2009\u00b1\u200947.37\u2009pg\/mL vs. CONT: 25.1\u2009\u00b1\u200943.8\u2009pg\/mL,\n p<\/jats:italic>\n \u2009=\u20090.02), and IL\u201017 (CF: 89.3\u2009\u00b1\u200953.37\u2009pg\/mL vs. CONT: 41.4\u2009\u00b1\u200942.5\u2009pg\/mL,\n p<\/jats:italic>\n \u2009=\u20090.03) were significantly elevated; Time\u2010domain variables were lower: SDNN (CF: 52\u2009\u00b1\u200924\u2009ms vs. CONT: 88\u2009\u00b1\u200931\u2009ms,\n p<\/jats:italic>\n \u2009=\u20090.04), RMSSD (CF: 41\u2009\u00b1\u200921\u2009ms vs. CONT: 68\u2009\u00b1\u200934\u2009ms,\n p<\/jats:italic>\n \u2009=\u20090.02), pNN50 (CF: 20%\u2009\u00b1\u200916.3% vs. CONT: 35%\u2009\u00b1\u200919.1%,\n p<\/jats:italic>\n \u2009=\u20090.03); in the frequency domain, only low frequency (LF) was lower (CF: 1061\u2009\u00b1\u20091335\u2009ms\n 2<\/jats:sup>\n vs. CONT: 2979\u2009\u00b1\u20094896\u2009ms\n 2<\/jats:sup>\n ,\n p<\/jats:italic>\n \u2009=\u20090.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Children and adolescents with CF exhibit increased oxidative stress, systemic inflammation, and reduced sympathetic and parasympathetic activity, as well as associations among lung function, HRV, and antioxidant capacity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ped.70448","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:15:28Z","timestamp":1782098128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Redox Profile, Inflammatory and Cardiac Autonomic Nervous Activity of Children and Adolescents With Cystic Fibrosis"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8681-2824","authenticated-orcid":false,"given":"Ana Carla Lima","family":"de Fran\u00e7a","sequence":"first","affiliation":[{"name":"Department of Nutrition. Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Nutri\u00e7\u00e3o Universidade Federal da Para\u00edba Jo\u00e3o Pessoa Brazil"},{"name":"Laboratory of Physical Training Studies Applied to Performance and Health Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1071-5264","authenticated-orcid":false,"given":"Mateus Duarte","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Training Studies Applied to Performance and Health Jo\u00e3o Pessoa Brazil"},{"name":"Department of Physical Education Programa Associado de P\u00f3s\u2010Gradua\u00e7\u00e3o em Educa\u00e7\u00e3o F\u00edsica Universidade de Pernambuco\/Universidade Federal da Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7842-540X","authenticated-orcid":false,"given":"Ana Carolina Freitas","family":"Meireles","sequence":"additional","affiliation":[{"name":"Department of Physical Education Programa Associado de P\u00f3s\u2010Gradua\u00e7\u00e3o em Educa\u00e7\u00e3o F\u00edsica Universidade de Pernambuco\/Universidade Federal da Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0020-6220","authenticated-orcid":false,"given":"Lydiane Tavares","family":"Toscano","sequence":"additional","affiliation":[{"name":"Department of Nutrition. Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Nutri\u00e7\u00e3o Universidade Federal da Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6806-3663","authenticated-orcid":false,"given":"Larissa Ara\u00fajo","family":"Maia","sequence":"additional","affiliation":[{"name":"Department of Nutrition. Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Nutri\u00e7\u00e3o Universidade Federal da Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6763-6594","authenticated-orcid":false,"given":"Constantino Giovanni Braga","family":"Cartaxo","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7781-5131","authenticated-orcid":false,"given":"Gilvan da Cruz Barbosa","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba Jo\u00e3o Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7885-4837","authenticated-orcid":false,"given":"Maria da Concei\u00e7\u00e3o Rodrigues","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Nutrition. 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