{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:09:36Z","timestamp":1783930176998,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":193,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Delays in end\u2010of\u2010life (EOL) decisions and prolonged life\u2010sustaining treatments (LST) are common in pediatric intensive care units (PICUs), but the influence of underlying disease on EOL decision\u2010making remains unclear. We compared EOL decision patterns and LST practices between oncology and non\u2010oncology patients in PICUs.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This retrospective study was conducted at two tertiary PICUs in Seoul, Korea (March 2023\u2013February 2025 at one center; March 2024\u2013February 2025 at the other). Inclusion criteria were patients (0\u201325\u2009years) admitted to the PICU with a documented EOL decision.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 55 patients, 23 were oncology and 32 were non\u2010oncology. Non\u2010oncology patients were younger (median 4.8 vs. 10.8\u2009years,\n p<\/jats:italic>\n \u2009=\u20090.040), had more pre\u2010PICU CPR (\n p<\/jats:italic>\n \u2009=\u20090.004), and higher Pediatric Logistic Organ Dysfunction\u20102 (PELOD\u20102) scores (\n p<\/jats:italic>\n \u2009=\u20090.001). Time from PICU admission to EOL decision (15.5 vs. 5.0\u2009days,\n p<\/jats:italic>\n \u2009=\u20090.034) was longer in non\u2010oncology patients. Palliative care consultation at EOL decision was more frequent among non\u2010oncology patients (78.1% vs. 47.8%,\n p<\/jats:italic>\n \u2009=\u20090.025). In exploratory multivariable negative binomial regression adjusting for age and PELOD\u20102, non\u2010oncology status was associated with a longer time from PICU admission to documented EOL decision (IRR 2.13, 95% CI 1.05\u20134.35). Withdrawal of LST was more common in non\u2010oncology patients (65.6% vs. 26.1%), while no escalation of support was more common in oncology patients (60.9% vs. 31.3%,\n p<\/jats:italic>\n \u2009=\u20090.011).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n EOL decision timing and care patterns differed between oncology and non\u2010oncology patients, suggesting disease trajectory may influence EOL decision\u2010making in PICUs.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ped.70479","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:36:07Z","timestamp":1783928167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["End\u2010of\u2010Life Care Patterns by Disease Trajectory in Pediatric Intensive Care Units: A Multicenter Study"],"prefix":"10.1111","volume":"68","author":[{"given":"Yonghyuk","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Pediatrics Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunggang","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawoon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nursing Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joosun","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nursing Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wonjin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4962-3810","authenticated-orcid":false,"given":"In Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Medicine The Catholic University of Korea Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June Dong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"156","article-title":"Changes in Pediatric End\u2010Of\u2010Life Process After the Enforcement of the Act on Life\u2010Sustaining Treatment Decisions\u2014The Experience of a Single Children's Hospital","volume":"25","author":"Roh D.\u2010E.","year":"2024","journal-title":"Health"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.resuscitation.2022.09.007","article-title":"Effect of Life\u2010Sustaining Treatment Decision Law on Pediatric In\u2010Hospital Cardiopulmonary Resuscitation Rate: A Korean Population\u2010Based Study","volume":"180","author":"Choi J.","year":"2022","journal-title":"Resuscitation"},{"issue":"4","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jped.2023.02.003","article-title":"End\u2010Of\u2010Life Care in Brazilian Pediatric Intensive Care Units","volume":"99","author":"Sousa I. 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