{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T07:03:45Z","timestamp":1784703825120,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":201,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K08281"],"award-info":[{"award-number":["15K08281"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K08165"],"award-info":[{"award-number":["20K08165"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Pediatric obesity is a growing global health challenge, and effective and sustainable therapeutic options remain limited. Although lifestyle modifications remain the cornerstone of treatment, pharmacological and surgical interventions are restricted among pediatric populations, highlighting the need for novel pathophysiology\u2010based strategies. Increasing evidence indicates that the renin\u2010angiotensin system, particularly the nonclassical angiotensin\u2010converting enzyme 2 (ACE2)\/angiotensin 1\u20137 (Ang1\u20107)\/Mas receptor (MasR) axis, plays an important role in metabolic regulation beyond classical cardiovascular functions. The ACE2\/Ang1\u20107\/MasR axis exerts pleiotropic metabolic effects, including anti\u2010inflammatory and insulin\u2010sensitizing actions, and has emerged as a key regulator of adipose tissue biology. Experimental studies have demonstrated that activation of this pathway stimulates brown adipose tissue (BAT), induces browning of white adipose tissue (WAT), and increases energy expenditure, thereby attenuating diet\u2010induced obesity and attracting considerable attention as potential therapeutic targets. However, accumulating evidence from human imaging studies and experimental models suggests that BAT activity and thermogenic plasticity decline with age, which may affect the metabolic efficacy of interventions targeting thermogenic adipose tissue. Age\u2010related differences in adipose tissue responsiveness may therefore contribute to discrepancies among previous studies examining Ang1\u20107\u2010mediated thermogenic effects. This review summarized the current evidence regarding the role of the ACE2\/Ang1\u20107\/MasR axis in regulating thermogenic adipose tissue, with a focus on BAT activation and WAT browning in obesity. We further discuss age\u2010related considerations that may modulate responsiveness to this pathway. Given that BAT activity is intrinsically high during childhood and adolescence, ACE2\/Ang1\u20107 axis modulation may represent a promising therapeutic strategy for pediatric obesity.<\/jats:p>","DOI":"10.1111\/ped.70490","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:12:27Z","timestamp":1784700747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ACE2\/Angiotensin 1\u20107\/Mas Receptor Axis in Thermogenic Adipose Tissue: Age\u2010Related Implications for Pediatric Obesity"],"prefix":"10.1111","volume":"68","author":[{"given":"Jun","family":"Mori","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, Metabolism and Nephrology, Children's Medical Center Osaka City General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Obesity Federation \u201cPrevalence of Obesity\u201d(2025) https:\/\/www.worldobesity.org\/about\/about\u2010obesity\/prevalence\u2010of\u2010obesity."},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jpeds.2006.08.042","article-title":"Cardiovascular Risk Factors and Excess Adiposity Among Overweight Children and Adolescents: The Bogalusa Heart Study","volume":"150","author":"Freedman D. 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