{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:34:03Z","timestamp":1786448043319,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":222,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rapid glucose assessment is essential in neonatal intensive care units (NICUs) for early detection of hypoglycemia. We evaluated the agreement between neonatal blood glucose levels measured using bedside blood gas analyzers (GasBS) and those measured in the central laboratory (LabBS), and identified factors associated with clinically significant discrepancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 5436 paired specimens from 2105 infants admitted to the NICU. For the primary agreement analyses, 5375 specimens with GasBS &gt;\u200920\u2009mg\/dL were included. Agreement between GasBS and LabBS was assessed using Bland\u2013Altman analysis, correlation analysis, and linear mixed models. Factors associated with clinically significant discrepancies (absolute difference \u2265\u200910\u2009mg\/dL) were evaluated using generalized linear mixed models. Exploratory receiver operating characteristic analysis was performed to assess the ability of GasBS to detect LabBS &lt;\u200940\u2009mg\/dL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GasBS and LabBS showed good agreement, with a mean difference of 1.88\u2009mg\/dL (95% limits of agreement, \u221212.56 to 16.32\u2009mg\/dL) and a strong correlation (Spearman's\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.939,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Lower base excess, lower oxygenated hemoglobin, and higher postnatal age were associated with greater discrepancies, whereas higher hematocrit was associated with an increased risk of clinically significant discrepancies. GasBS also showed excellent performance in detecting LabBS &lt;\u200940\u2009mg\/dL, with an area under the receiver operating characteristic curve of 0.985 and an optimal cutoff of 43.5\u2009mg\/dL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Blood gas analyzers provide clinically useful glucose measurements in newborns. However, discrepancies from central laboratory measurements may occur under certain physiological conditions, and confirmatory testing remains essential when severe hypoglycemia is suspected.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70511","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:56:06Z","timestamp":1786445766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood Glucose Monitoring in the Neonatal Period: A Study on Evaluation Using the\n                    <scp>RAPIDPoint<\/scp>\n                    500\/500e"],"prefix":"10.1111","volume":"68","author":[{"given":"Izumi","family":"Kurosawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-6884","authenticated-orcid":false,"given":"Hiroshi","family":"Miyabayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"},{"name":"Department of Pediatrics Kasukabe Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasue","family":"Goko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"},{"name":"Department of Pediatrics Kasukabe Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"},{"name":"Department of Pediatrics Kasukabe Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"},{"name":"Department of Pediatrics Kasukabe Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"},{"name":"Department of Pediatrics Kasukabe Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-1626","authenticated-orcid":false,"given":"Nobuhiko","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5685-2670","authenticated-orcid":false,"given":"Ichiro","family":"Morioka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000492859","article-title":"Neonatal Glycaemia and Neurodevelopmental Outcomes: A Systematic Review and Meta\u2010Analysis","volume":"115","author":"Shah R.","year":"2019","journal-title":"Neonatology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/pch\/pxab079","article-title":"The Clinical Effect of Glucose Meter Selection Upon the Detection of Neonatal Hypoglycemia","volume":"27","author":"Parker K.","year":"2022","journal-title":"Paediatrics & Child Health"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jpeds.2015.03.057","article-title":"Recommendations From the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children","volume":"167","author":"Thornton P. 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C.","year":"2020","journal-title":"Journal of Clinical Laboratory Analysis"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1258\/000456302320314539","article-title":"Point\u2010Of\u2010Care Testing of Blood Glucose in the Neonatal Unit Using the AVL Omni 9 Analyser","volume":"39","author":"Newman J. D.","year":"2002","journal-title":"Annals of Clinical Biochemistry"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169593","article-title":"Point\u2010Of\u2010Care Versus Central Laboratory Measurements of Hemoglobin, Hematocrit, Glucose, Bicarbonate and Electrolytes: A Prospective Observational Study in Critically Ill Patients","volume":"12","author":"Allardet\u2010Servent J.","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_11_12_1","first-page":"10","article-title":"Diagnosis and Management of Neonatal Hypoglycemia: A Comprehensive Review of Guidelines","volume":"10","author":"Giouleka S.","year":"2023","journal-title":"Children (Basel)"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the Freely Available Easy\u2010to\u2010Use Software \u2018EZR\u2019 for Medical Statistics","volume":"48","author":"Kanda Y.","year":"2013","journal-title":"Bone Marrow Transplantation"},{"key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1515\/cclm-2012-0436","article-title":"Hematocrit Correction Does Not Improve Glucose Monitor Accuracy in the Assessment of Neonatal Hypoglycemia","volume":"51","author":"Wang L.","year":"2013","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"e_1_2_11_15_1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1089\/dia.2013.0160","article-title":"Point\u2010Of\u2010Care Glucose Analysis in Neonates Using Modified Quinoprotein Glucose Dehydrogenase","volume":"15","author":"Dietzen D. J.","year":"2013","journal-title":"Diabetes Technology & Therapeutics"},{"key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/pch\/pxz134","article-title":"The Screening and Management of Newborns at Risk for Low Blood Glucose","volume":"24","author":"Narvey M. R.","year":"2019","journal-title":"Paediatrics & Child Health"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70511","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:56:08Z","timestamp":1786445768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ped.70511"],"URL":"https:\/\/doi.org\/10.1111\/ped.70511","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70511"}}