{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:28:32Z","timestamp":1787225312943,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":231,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH.110\u2010T05"],"award-info":[{"award-number":["NTUH.110\u2010T05"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH.111\u2010T0009"],"award-info":[{"award-number":["NTUH.111\u2010T0009"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH. 112\u2010E0009"],"award-info":[{"award-number":["NTUH. 112\u2010E0009"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biliary atresia (BA) is the leading cause of pediatric liver transplantation worldwide. However, the genetic background remains unclear in most patients. In this genome\u2010wide association study (GWAS), we aimed to identify genetic loci that contribute to susceptibility to BA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited 189 BA patients (85 males and 104 females) and 558 non\u2010BA controls (275 males and 283 females) for this GWAS analysis using the Axiom Genome\u2010Wide TWB 2.0 Array with 686,463 single\u2010nucleotide polymorphisms (SNPs). The MassARRAY Sequenom analysis was then applied to validate the identified top SNPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified rs139120621 (odds ratio [OR]\u2009=\u200917.31,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20092.78\u2009\u00d7\u200910\n                      <jats:sup>\u22129<\/jats:sup>\n                      ) at 8q22.1, which is mapped to the\n                      <jats:italic>FLJ46284<\/jats:italic>\n                      gene, significantly correlated with BA in this Taiwanese cohort. The rs113128512 located at chromosome 4q32.1 (OR\u2009=\u20099.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.30\u2009\u00d7\u200910\n                      <jats:sup>\u22126<\/jats:sup>\n                      ), and rs11193325 (OR\u2009=\u20091.85,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20098.20\u2009\u00d7\u200910\n                      <jats:sup>\u22126<\/jats:sup>\n                      ) at 10q25.1 are also associated with BA. The rs113128512 is mapped to the\n                      <jats:italic>PDGFC<\/jats:italic>\n                      gene, and rs11193325 is downstream of the\n                      <jats:italic>SORCS1<\/jats:italic>\n                      gene.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We identified novel loci of BA susceptibility SNPs in a Taiwanese cohort by the GWAS analysis. These findings shed light on the genetic factors in the pathophysiology of BA that might be applied to the future development of therapeutic agents for BA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70521","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:06:26Z","timestamp":1787223986000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loci Associated With Susceptibility to Biliary Atresia\u2014A Genome\u2010Wide Association Study in Taiwan"],"prefix":"10.1111","volume":"68","author":[{"given":"Chieh\u2010Yu","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital Yunlin Branch  Douliu City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010San","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Ting","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital Hsinchu Branch  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-3810","authenticated-orcid":false,"given":"Kai\u2010Chi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4074-5838","authenticated-orcid":false,"given":"Huey\u2010Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-5249","authenticated-orcid":false,"given":"Yen\u2010Hsuan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Pediatrics, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3648-9261","authenticated-orcid":false,"given":"Mei\u2010Hwei","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Pediatrics, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6343-1658","authenticated-orcid":false,"given":"Jia\u2010Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Pediatrics, College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/hep.21790","article-title":"Screening and Outcomes in Biliary Atresia: Summary of a National Institutes of Health Workshop","volume":"46","author":"Sokol R. 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H.","year":"2019","journal-title":"International Journal of Medical Sciences"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70521","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:06:32Z","timestamp":1787223992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ped.70521"],"URL":"https:\/\/doi.org\/10.1111\/ped.70521","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70521"}}