{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:29:04Z","timestamp":1787840944885,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":238,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric home mechanical ventilation (HMV) use has risen globally, driven by advances in pediatric critical care and a shift toward community\u2010based management. However, long\u2010term outcome data from Japanese regional core hospitals remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a single\u2010center retrospective cohort study of all patients between 1995 and 2024 aged \u2264\u200920\u2009years for whom there was initiation of HMV (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937). HMV included invasive mechanical ventilation (tracheostomy positive\u2010pressure ventilation) and\/or noninvasive ventilation. Cumulative survival after HMV initiation was estimated using the Kaplan\u2013Meier method and compared using log\u2010rank tests according to age at initiation (\u2264\u20097 vs. &gt;\u20097\u2009years), ventilation modality (invasive mechanical ventilation vs. noninvasive ventilation), predominant pathophysiological indication (respiratory pump insufficiency [Pump], airway disease [Airway], or restrictive lung mechanics [Restrictive]), and presence of severe motor and intellectual disabilities (SMID).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Kaplan\u2013Meier\u2013estimated cumulative survival was 69.1% (maximum follow\u2010up, 29.1\u2009years). In our cohort, survival did not significantly differ by age at initiation or ventilation modality. In contrast, it was significantly lower in patients with restrictive lung mechanics and lower in those with SMID. Among the eight deaths, cardiac disease was common, and death was seen to be clustered in the winter months; it often followed respiratory infections, and it was associated with notable growth impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that children receiving HMV can achieve long\u2010term survival. Nevertheless, high\u2010risk groups, particularly those with restrictive lung mechanics or SMID, warrant risk\u2010stratified care, proactive prevention of winter infection, and timely advance care planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70534","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:32:40Z","timestamp":1787837560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics of Pediatric Patients With Home Mechanical Ventilation in a Japanese Regional Core Hospital"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3852-9845","authenticated-orcid":false,"given":"Toshinori","family":"Minato","sequence":"first","affiliation":[{"name":"Department of Pediatrics Toyooka Hospital  Toyooka Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9611-1486","authenticated-orcid":false,"given":"Dai","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyooka Hospital  Toyooka Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-0233","authenticated-orcid":false,"given":"Hiroyuki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyooka Hospital  Toyooka Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Fujibayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Toyooka Hospital  Toyooka Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norishige","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Clinical Research Center Takatsuki General Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010025\u201006559\u2010x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2022-059898","article-title":"Incidence and Mortality of Children Receiving Home Mechanical Ventilation","volume":"151","author":"Amin R.","year":"2023","journal-title":"Pediatrics"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010023\u201005249\u2010w"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax\u20102023\u2010220888"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010025\u201001920\u20100"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052\u2010020\u20100778\u20108"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.sleep.2018.04.004","article-title":"Home Continuous Positive Airway Pressure for Cardiopulmonary Indications in Infants and Children","volume":"48","author":"Al\u2010Iede M.","year":"2018","journal-title":"Sleep Medicine"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192111"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.braindev.2018.03.006","article-title":"Long\u2010Term Home Non\u2010Invasive Positive Pressure Ventilation: Results From a Single Center in Japan","volume":"40","author":"Ikeda A.","year":"2018","journal-title":"Brain & Development"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23925"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jpeds.2010.06.012","article-title":"Outcomes and Causes of Death in Children on Home Mechanical Ventilation via Tracheostomy: An Institutional and Literature Review","volume":"157","author":"Edwards J. D.","year":"2010","journal-title":"Journal of Pediatrics"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/082585971202800104","article-title":"End\u2010Of\u2010Life Discussions and Advance Care Planning for Children on Long\u2010Term Assisted Ventilation With Life\u2010Limiting Conditions","volume":"28","author":"Edwards J. D.","year":"2012","journal-title":"Journal of Palliative Care"},{"key":"e_1_2_10_14_1","unstructured":"Japanese Ministry of Health Labour and Welfare \u201cNotification \u201d(2021) https:\/\/www.mhlw.go.jp\/content\/000763142.pdf."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00333"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70534","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:32:42Z","timestamp":1787837562000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ped.70534"],"URL":"https:\/\/doi.org\/10.1111\/ped.70534","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70534"}}