{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:03:15Z","timestamp":1790672595175,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":271,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013238","name":"Faculty of Medicine Siriraj Hospital, Mahidol University","doi-asserted-by":"publisher","award":["R015934009"],"award-info":[{"award-number":["R015934009"]}],"id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Youth\u2010onset diabetes is a chronic condition requiring lifelong management, and achieving optimal glycemic control remains challenging. This study aimed to delineate etiologies of youth\u2010onset diabetes among Thai patients. We further examined clinical characteristics, therapeutic outcomes, and factors associated with glycemic control in type 1 diabetes (T1D) and type 2 diabetes (T2D).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a prospective cross\u2010sectional Pediatric Diabetes Registry Project in 2 phases: initial (March 2016\u2013August 2018) and follow\u2010up (March 2019\u2013March 2020). Individuals diagnosed before age 18\u2009years were recruited. Data on clinical profile, glycemic control, treatment, and complications were collected.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Three hundred participants were recruited at baseline. The majority (77%,\n n<\/jats:italic>\n \u2009=\u2009231) had T1D, and 15.3% (\n n<\/jats:italic>\n \u2009=\u200946) had T2D. The mean HbA1c in T1D was 8.96%\u2009\u00b1\u20091.98%, with 22.5% achieving good glycemic control. Multivariate analysis revealed that older age (OR 1.16, 95% CI 1.01\u20131.32,\n p<\/jats:italic>\n \u2009=\u20090.031) and self\u2010monitoring of blood glucose (SMBG) \u2265\u20094\u2009times\/day (OR\u20094.85, 95% CI 1.85\u201312.71,\n p<\/jats:italic>\n \u2009=\u20090.001) were positively associated with good control. Among T2D patients, mean HbA1c was 7.55%\u2009\u00b1\u20092.21%, and 56.5% achieved good control. Longer disease duration (OR 0.40, 95% CI 0.21\u20130.74,\n p<\/jats:italic>\n \u2009=\u20090.003) predicted suboptimal control. At follow\u2010up, the prevalence of diabetic nephropathy increased in T1D (from 3.4% to 5.8%) and T2D (from 9.1% to 17.4%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Most T1D patients exhibited suboptimal glycemic control, while older age and frequent SMBG predicted better outcomes. In T2D, longer disease duration correlated inversely with glycemic control, highlighting the need for proactive interventions.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ped.70544","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:19:28Z","timestamp":1790669968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Etiologies, Clinical Profiles, and Treatment Outcomes in Thai Children and Adolescents With Youth\u2010Onset Diabetes"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4887-081X","authenticated-orcid":false,"given":"Pranchalee","family":"Srikanchanawat","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4726-9360","authenticated-orcid":false,"given":"Jeerunda","family":"Santiprabhob","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"},{"name":"Siriraj Diabetes Center of Excellence, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9435-8470","authenticated-orcid":false,"given":"Supawadee","family":"Likitmaskul","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"},{"name":"Siriraj Diabetes Center of Excellence, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7521-5733","authenticated-orcid":false,"given":"Khwanhatai","family":"Khemaprasit","sequence":"additional","affiliation":[{"name":"Siriraj Diabetes Center of Excellence, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-085X","authenticated-orcid":false,"given":"Parichat","family":"Charoentawornpanich","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-5803","authenticated-orcid":false,"given":"Thanida","family":"Tangjarusritaratorn","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-8699","authenticated-orcid":false,"given":"Supitcha","family":"Patjamontri","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2087-5149","authenticated-orcid":false,"given":"Ornsuda","family":"Lertbannaphong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3469-8061","authenticated-orcid":false,"given":"Teerarat","family":"Manpayak","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0952-6386","authenticated-orcid":false,"given":"Pornpimol","family":"Kiattisakthavee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7796-8712","authenticated-orcid":false,"given":"Kanyarat","family":"Wongmuan","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7103-8466","authenticated-orcid":false,"given":"Watip","family":"Tangjittipokin","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"},{"name":"Siriraj Center of Research Excellence for Diabetes and Obesity, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/jdi.13732","article-title":"Young\u2010Onset Diabetes Patients in Thailand: Data From Thai Type\u20091 Diabetes and Diabetes Diagnosed Age Before 30\u2009Years Registry, Care and Network (T1DDAR CN)","volume":"13","author":"Dejkhamron 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