{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:49:47Z","timestamp":1791881387019,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":285,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016342","name":"Ministry of Health Mexico","doi-asserted-by":"publisher","award":["26AA2006"],"award-info":[{"award-number":["26AA2006"]}],"id":[{"id":"10.13039\/100016342","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The temporal association between influenza and immune thrombocytopenia (ITP) is poorly characterized. This study examined the risk interval between influenza infection and newly diagnosed ITP in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled individuals aged 1\u201315\u2009years newly diagnosed with ITP between 2005 and 2024, using the Japanese large\u2010scale administrative JMDC Database. We conducted a nested case\u2013control study and self\u2010controlled case series to evaluate the risk of ITP within 28\u2009days (categorized into 7\u2010day intervals) of influenza diagnosis. We estimated the risk interval from influenza diagnosis to ITP onset using conditional logistic and Poisson regressions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 2255 individuals diagnosed with ITP, of whom 1324 met the eligibility criteria. In the nested case\u2013control analysis, the adjusted odds ratio of preceding influenza diagnosis was the highest within 1\u20137\u2009days before ITP onset (3.13; 95% confidence interval 1.38\u20137.12) compared with the matched controls. In the self\u2010controlled case series, the incidence rate ratio for ITP was the highest within 1\u20137\u2009days after influenza diagnosis compared to the baseline period (2.44; 95% confidence interval 1.16\u20135.14). In the sensitivity and post hoc analyses for different definitions of influenza diagnosis and ITP onset dates, ITP onset peaked within 1\u201314\u2009days of influenza diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The risk of ITP appeared to be highest during the first 1\u20132\u2009weeks after influenza diagnosis, particularly around the first week.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70582","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:15:02Z","timestamp":1791879302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Interval of Immune Thrombocytopenia in Children After Influenza Infection"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-054X","authenticated-orcid":false,"given":"Kyosuke","family":"Ibi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Clinical Epidemiology and Health Economics, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-2946","authenticated-orcid":false,"given":"Yoshihisa","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Real\u2010World Evidence, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-1774","authenticated-orcid":false,"given":"Motohiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6017-469X","authenticated-orcid":false,"given":"Hideo","family":"Yasunaga","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1182\/bloodadvances.2019000966","article-title":"American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia","volume":"3","author":"Neunert C.","year":"2019","journal-title":"Blood Advances"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0955-3886(98)00039-3","article-title":"Virus\u2010Associated Idiopathic Thrombocytopenic Purpura","volume":"19","author":"Rand M. 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G.","year":"2020","journal-title":"Blood Advances"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3324\/haematol.2019.240440","article-title":"Desialylation of O\u2010Glycans on Glycoprotein Ibalpha Drives Receptor Signaling and Platelet Clearance","volume":"106","author":"Wang Y.","year":"2021","journal-title":"Haematologica"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jhin.2018.11.010","article-title":"Implementation of Influenza Point\u2010Of\u2010Care Testing and Patient Cohorting During a High\u2010Incidence Season: A Retrospective Analysis of Impact on Infection Prevention and Control and Clinical Outcomes","volume":"101","author":"Youngs J.","year":"2019","journal-title":"Journal of Hospital Infection"},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.3324\/haematol.2022.282524","article-title":"Adolescents and Young Adults With Newly Diagnosed Primary Immune Thrombocytopenia","volume":"108","author":"Schifferli A.","year":"2023","journal-title":"Haematologica"}],"container-title":["Pediatrics International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ped.70582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ped.70582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:15:06Z","timestamp":1791879306000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ped.70582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ped.70582"],"URL":"https:\/\/doi.org\/10.1111\/ped.70582","archive":["Portico"],"relation":{},"ISSN":["1328-8067","1442-200X"],"issn-type":[{"value":"1328-8067","type":"print"},{"value":"1442-200X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70582"}}