{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:47:10Z","timestamp":1791964030088,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":286,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatrics International"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate temporal changes in serum interleukin\u201040 (IL\u201040), hypoxia\u2010inducible factor\u20101 alpha (HIF\u20101\u03b1), and procalcitonin (PCT) levels between early and post\u2010rewarming measurements in neonates with moderate\u2010to\u2010severe hypoxic\u2013ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH), and to determine the prognostic value of these biomarkers together with the Hammersmith Neonatal Neurological Examination (HNNE), amplitude\u2010integrated electroencephalography (aEEG), and magnetic resonance imaging (MRI) for predicting cerebral palsy (CP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010five neonates with HIE treated with TH and 20 healthy term neonates were prospectively enrolled. Serum IL\u201040, HIF\u20101\u03b1, and PCT levels were measured before and after TH. Associations between biomarkers, HNNE, aEEG, MRI findings, and CP at follow\u2010up were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum IL\u201040, HIF\u20101\u03b1, and PCT levels decreased significantly between the early and post\u2010rewarming measurements (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Although biomarker levels differed from controls, they were not associated with subsequent CP. In contrast, HNNE, aEEG, and MRI showed strong prognostic performance for subsequent CP among surviving infants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum IL\u201040, HIF\u20101\u03b1, and PCT levels showed significant temporal decreases between the early and post\u2010rewarming measurements in neonates with HIE undergoing TH; however, these biomarkers did not predict subsequent CP among surviving infants. HNNE, aEEG, and MRI each demonstrated strong prognostic performance for subsequent CP when evaluated individually in this cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ped.70585","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:13:11Z","timestamp":1791961991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neurological Assessment Tools and Inflammatory Biomarkers for Predicting Cerebral Palsy in Neonatal\n                    <scp>HIE<\/scp>"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0951-8258","authenticated-orcid":false,"given":"Celil","family":"Y\u0131lmaz","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Alanya Training and Research Hospital University of Health Sciences  Antalya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-621X","authenticated-orcid":false,"given":"Fatih","family":"\u0130\u015fleyen","sequence":"additional","affiliation":[{"name":"Department of Neonatology \u015eanl\u0131urfa Training and Research Hospital  \u015eanl\u0131urfa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-4757","authenticated-orcid":false,"given":"\u0130smail","family":"Koyuncu","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine Harran University  \u015eanl\u0131urfa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-6697","authenticated-orcid":false,"given":"Osman","family":"Kipo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology Kartal Dr. L\u00fctfi K\u0131rdar City Hospital  \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010023\u201002741\u20109"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.1772"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11051319"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179764"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.021"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.703084"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700534"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/3968767"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201080104\u2010y"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2021.9690"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkArchPediatr.2024.24089"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.5152\/TurkPediatriArs.2018.01805"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15512"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.16277"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.7\u20102\u2010e76"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102011\u2010301524"},{"issue":"1","key":"e_1_2_13_19_1","first-page":"143","article-title":"Prediction of Neuromotor Outcome in Perinatal Asphyxia: Evaluation of MR Scoring Systems","volume":"19","author":"Barkovich A. 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