{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:39:52Z","timestamp":1781663992925,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["1RO1DK098517-01A1"],"award-info":[{"award-number":["1RO1DK098517-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01 DK098517-03S1"],"award-info":[{"award-number":["R01 DK098517-03S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R37-DK056268"],"award-info":[{"award-number":["R37-DK056268"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIH)","doi-asserted-by":"crossref","award":["DK007314-35"],"award-info":[{"award-number":["DK007314-35"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Diabetes"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1111\/pedi.12507","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T11:46:54Z","timestamp":1486381614000},"page":"911-916","source":"Crossref","is-referenced-by-count":17,"title":["A severe case of hyperinsulinism due to hemizygous activating mutation of glutamate dehydrogenase"],"prefix":"10.1155","volume":"18","author":[{"given":"Mary","family":"Barrosse-Antle","sequence":"first","affiliation":[{"name":"Department of Pediatrics; Perelman School of Medicine at the University of Pennsylvania; Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Su","sequence":"additional","affiliation":[{"name":"Endocrinology Genetics and Metabolism Department; Beijing Children's Hospital, Capital Medical University; Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes; The Children's Hospital of Philadelphia; Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara E","family":"Boodhansingh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes; The Children's Hospital of Philadelphia; Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology; University of Texas Medical Branch at Galveston; Galveston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A","family":"Stanley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Perelman School of Medicine at the University of Pennsylvania; Philadelphia Pennsylvania"},{"name":"Division of Endocrinology and Diabetes; The Children's Hospital of Philadelphia; Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diva D","family":"De Le\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Perelman School of Medicine at the University of Pennsylvania; Philadelphia Pennsylvania"},{"name":"Division of Endocrinology and Diabetes; The Children's Hospital of Philadelphia; Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0513-1459","authenticated-orcid":false,"given":"Changhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Perelman School of Medicine at the University of Pennsylvania; Philadelphia Pennsylvania"},{"name":"Division of Endocrinology and Diabetes; The Children's Hospital of Philadelphia; Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"issue":"19","key":"10.1111\/pedi.12507-BIB0001|pedi12507-cit-0001","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1056\/NEJM199805073381904","article-title":"Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene","volume":"338","author":"Stanley","year":"1998","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1111\/pedi.12507-BIB0002|pedi12507-cit-0002","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/pedi.12453","article-title":"Congenital hypoglycemia disorders: new aspects of etiology, diagnosis, treatment and outcomes: highlights of the Proceedings of the Congenital Hypoglycemia Disorders Symposium, Philadelphia April 2016","volume":"18","author":"De Leon","year":"2016","journal-title":"Pediatr Diabetes"},{"issue":"3","key":"10.1111\/pedi.12507-BIB0003|pedi12507-cit-0003","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/pedi.12254","article-title":"Congenital hyperinsulinism in Chinese patients: 5-yr treatment outcome of 95 clinical cases with genetic analysis of 55 cases","volume":"17","author":"Gong","year":"2016","journal-title":"Pediatr Diabetes"},{"issue":"4","key":"10.1111\/pedi.12507-BIB0004|pedi12507-cit-0004","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuint.2010.10.017","article-title":"The structure and allosteric regulation of glutamate dehydrogenase","volume":"59","author":"Li","year":"2011","journal-title":"Neurochem Int"},{"issue":"11","key":"10.1111\/pedi.12507-BIB0005|pedi12507-cit-0005","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.tibs.2008.07.007","article-title":"Untangling the glutamate dehydrogenase allosteric nightmare","volume":"33","author":"Smith","year":"2008","journal-title":"Trends Biochem Sci"},{"issue":"39","key":"10.1111\/pedi.12507-BIB0006|pedi12507-cit-0006","doi-asserted-by":"crossref","first-page":"34164","DOI":"10.1074\/jbc.M111.268599","article-title":"Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site","volume":"286","author":"Li","year":"2011","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1111\/pedi.12507-BIB0007|pedi12507-cit-0007","first-page":"1782","article-title":"Hyperinsulinism\/hyperammonemia syndrome in children with regulatory mutations in the inhibitory guanosine triphosphate-binding domain of glutamate dehydrogenase","volume":"86","author":"MacMullen","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1111\/pedi.12507-BIB0008|pedi12507-cit-0008","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2337\/diabetes.49.4.667","article-title":"Molecular basis and characterization of the hyperinsulinism\/hyperammonemia syndrome: predominance of mutations in exons 11 and 12 of the glutamate dehydrogenase gene. HI\/HA Contributing Investigators","volume":"49","author":"Stanley","year":"2000","journal-title":"Diabetes"},{"issue":"pt 1","key":"10.1111\/pedi.12507-BIB0009|pedi12507-cit-0009","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1042\/bj3630081","article-title":"Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations","volume":"363","author":"Fang","year":"2002","journal-title":"Biochem J"},{"issue":"41","key":"10.1111\/pedi.12507-BIB0010|pedi12507-cit-0010","doi-asserted-by":"crossref","first-page":"31806","DOI":"10.1074\/jbc.M110.123638","article-title":"Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase","volume":"285","author":"Li","year":"2010","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1111\/pedi.12507-BIB0011|pedi12507-cit-0011","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1067\/mpd.2001.111818","article-title":"Protein-sensitive and fasting hypoglycemia in children with the hyperinsulinism\/hyperammonemia syndrome","volume":"138","author":"Hsu","year":"2001","journal-title":"J Pediatr"},{"issue":"3","key":"10.1111\/pedi.12507-BIB0012|pedi12507-cit-0012","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1203\/00006450-200109000-00010","article-title":"Hyperinsulinism and hyperammonemia syndrome: report of twelve unrelated patients","volume":"50","author":"De Lonlay","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1111\/pedi.12507-BIB0013|pedi12507-cit-0013","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jpeds.2015.09.045","article-title":"Biomarkers of insulin for the diagnosis of hyperinsulinemic hypoglycemia in infants and children","volume":"168","author":"Ferrara","year":"2016","journal-title":"J Pediatr"},{"issue":"12","key":"10.1111\/pedi.12507-BIB0014|pedi12507-cit-0014","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.2337\/db14-0783","article-title":"Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release","volume":"63","author":"Kibbey","year":"2014","journal-title":"Diabetes"},{"issue":"6","key":"10.1111\/pedi.12507-BIB0015|pedi12507-cit-0015","doi-asserted-by":"crossref","first-page":"E1219","DOI":"10.1152\/ajpendo.00028.2010","article-title":"Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism\/hyperammonemia syndrome","volume":"298","author":"Treberg","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"}],"container-title":["Pediatric Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpedi.12507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/pedi.12507\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T18:09:42Z","timestamp":1671818982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pedi.12507"}},"subtitle":["BARROSSE-ANTLE et al."],"short-title":[],"issued":{"date-parts":[[2017,2,6]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,12]]}},"URL":"https:\/\/doi.org\/10.1111\/pedi.12507","archive":["Portico"],"relation":{},"ISSN":["1399-543X"],"issn-type":[{"value":"1399-543X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2,6]]}}}