{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:03:39Z","timestamp":1790420619524,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Diabetes"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1111\/pedi.12650","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T20:23:10Z","timestamp":1519244590000},"page":"823-831","source":"Crossref","is-referenced-by-count":21,"title":["Factitious hypoglycemia in children and adolescents with diabetes"],"prefix":"10.1155","volume":"19","author":[{"given":"Viviana","family":"Bauman","sequence":"first","affiliation":[{"name":"Section of Pediatric Diabetes and Metabolism; DEOB, NIDDK, NIH; Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaya C","family":"Sturkey","sequence":"additional","affiliation":[{"name":"Section of Pediatric Diabetes and Metabolism; DEOB, NIDDK, NIH; Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sherafat-Kazemzadeh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Georgetown University Medical Center; Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"McEwan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Georgetown University Medical Center; Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Pediatrics; Georgetown University Medical Center; Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Keating","sequence":"additional","affiliation":[{"name":"Pediatric, Adolescent and Young Adult Unit; Joslin Diabetes Center; Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Isganaitis","sequence":"additional","affiliation":[{"name":"Pediatric, Adolescent and Young Adult Unit; Joslin Diabetes Center; Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyne","family":"Ricker","sequence":"additional","affiliation":[{"name":"Pediatric, Adolescent and Young Adult Unit; Joslin Diabetes Center; Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8421-131X","authenticated-orcid":false,"given":"Kristina I","family":"Rother","sequence":"additional","affiliation":[{"name":"Section of Pediatric Diabetes and Metabolism; DEOB, NIDDK, NIH; Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"10.1111\/pedi.12650-BIB0001|pedi12650-cit-0001","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0140-6736(51)92313-6","article-title":"Munchausen's syndrome","volume":"1","author":"Asher","year":"1951","journal-title":"Lancet"},{"key":"10.1111\/pedi.12650-BIB0002|pedi12650-cit-0002","first-page":"46","article-title":"Munchausen's syndrome and other factitious disorders in children: case series and literature review","volume":"3","author":"Jaghab","year":"2006","journal-title":"Psychiatry (Edgmont)"},{"key":"10.1111\/pedi.12650-BIB0003|pedi12650-cit-0003","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.genhosppsych.2016.05.002","article-title":"Factitious disorder: a systematic review of 455 cases in the professional literature","volume":"41","author":"Yates","year":"2016","journal-title":"Gen Hosp Psychiatry"},{"key":"10.1111\/pedi.12650-BIB0004|pedi12650-cit-0004","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0002-9343(85)90283-9","article-title":"Factitious brittle diabetes mellitus","volume":"78","author":"Schade","year":"1985","journal-title":"Am J Med"},{"key":"10.1111\/pedi.12650-BIB0005|pedi12650-cit-0005","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.2196\/jmir.2011","article-title":"Munchausen by internet: current research and future directions","volume":"14","author":"Pulman","year":"2012","journal-title":"J Med Internet Res"},{"key":"10.1111\/pedi.12650-BIB0006|pedi12650-cit-0006","first-page":"113","article-title":"Munchausen syndrome. Report of a case and a review of the literature","volume":"13","author":"Bagan","year":"1962","journal-title":"BMQ"},{"key":"10.1111\/pedi.12650-BIB0007|pedi12650-cit-0007","doi-asserted-by":"crossref","first-page":"252","DOI":"10.7326\/0003-4819-108-2-252","article-title":"Factitious hypoglycemia due to surreptitious administration of insulin. Diagnosis, treatment, and long-term follow-up","volume":"108","author":"Grunberger","year":"1988","journal-title":"Ann Intern Med"},{"key":"10.1111\/pedi.12650-BIB0008|pedi12650-cit-0008","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00019616-199205000-00006","article-title":"Factitial hypoglycemia","volume":"2","author":"Service","year":"1992","journal-title":"Endocrinologist"},{"key":"10.1111\/pedi.12650-BIB0009|pedi12650-cit-0009","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1056\/NEJM199504273321707","article-title":"Hypoglycemic disorders","volume":"332","author":"Service","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1111\/pedi.12650-BIB0010|pedi12650-cit-0010","first-page":"A102","article-title":"Detection of exogenous insulin use: cross-reactivity of synthetic insulins in serum with commercial immunoassays and absolute determination using a mass spectrometric assay","volume":"59","author":"Kaleta","year":"2013","journal-title":"Clin Chem"},{"key":"10.1111\/pedi.12650-BIB0011|pedi12650-cit-0011","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.clinbiochem.2015.07.017","article-title":"Commercial insulin immunoassays fail to detect commonly prescribed insulin analogues","volume":"48","author":"Parfitt","year":"2015","journal-title":"Clin Biochem"},{"key":"10.1111\/pedi.12650-BIB0012|pedi12650-cit-0012","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1111\/dme.13146","article-title":"A difficult case of recurrent hypoglycaemia: role of insulin assays in establishing the diagnosis","volume":"33","author":"Joshi","year":"2016","journal-title":"Diabet Med"},{"key":"10.1111\/pedi.12650-BIB0013|pedi12650-cit-0013","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4274\/jcrpe.1492","article-title":"Importance of insulin immunoassays in the diagnosis of factitious hypoglycemia","volume":"6","author":"Nalbantoglu Elmas","year":"2014","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"10.1111\/pedi.12650-BIB0014|pedi12650-cit-0014","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4158\/EP.14.8.1006","article-title":"Insulin immunoassays in the detection of insulin analogues in factitious hypoglycemia","volume":"14","author":"Neal","year":"2008","journal-title":"Endocr Pract"},{"key":"10.1111\/pedi.12650-BIB0015|pedi12650-cit-0015","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1055\/s-0028-1111123","article-title":"Hypoglycemia factitia. A differential diagnostic significant form of hyperinsulinism","volume":"94","author":"Creutzfeldt","year":"1969","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1111\/pedi.12650-BIB0016|pedi12650-cit-0016","first-page":"32","article-title":"Hypoglycemia provoked by clandestine injections of insulin in the diabetic child","volume":"40","author":"Jezequel","year":"1993","journal-title":"Ann Pediatr (Paris)"},{"key":"10.1111\/pedi.12650-BIB0017|pedi12650-cit-0017","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1210\/jcem.86.2.7160","article-title":"Repaglinide-induced factitious hypoglycemia","volume":"86","author":"Hirshberg","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/pedi.12650-BIB0018|pedi12650-cit-0018","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/000992289603500309","article-title":"Recurrent hypoglycemia and obesity in an adolescent-insulinoma or imitator?","volume":"35","author":"Scott","year":"1996","journal-title":"Clin Pediatr (Phila)"},{"key":"10.1111\/pedi.12650-BIB0019|pedi12650-cit-0019","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3109\/15563650.2015.1122793","article-title":"Prolonged hypoglycemia after a suicidal ingestion of repaglinide with unexpected slow plasma elimination","volume":"54","author":"Elling","year":"2016","journal-title":"Clin Toxicol (Phila)"},{"key":"10.1111\/pedi.12650-BIB0020|pedi12650-cit-0020","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s13181-010-0110-x","article-title":"Case files of the Harvard Medical Toxicology Fellowship at Children's Hospital Boston: an insulin overdose","volume":"6","author":"Skolnik","year":"2010","journal-title":"J Med Toxicol"},{"key":"10.1111\/pedi.12650-BIB0021|pedi12650-cit-0021","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/pedi.12210","article-title":"Intravenous glucagon in a deliberate insulin overdose in an adolescent with type 1 diabetes mellitus","volume":"17","author":"White","year":"2016","journal-title":"Pediatr Diabetes"},{"key":"10.1111\/pedi.12650-BIB0022|pedi12650-cit-0022","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0025-7125(16)35848-5","article-title":"Hyperinsulinism among malingerers","volume":"31","author":"Rynearson","year":"1947","journal-title":"Med Clin North Am"},{"key":"10.1111\/pedi.12650-BIB0023|pedi12650-cit-0023","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1056\/NEJM197711102971903","article-title":"Factitious hypoglycemia. Diagnosis by measurement of serum C-peptide immunoreactivity and insulin-binding antibodies","volume":"297","author":"Scarlett","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1111\/pedi.12650-BIB0024|pedi12650-cit-0024","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1001\/jama.1986.03380230051024","article-title":"Surreptitious insulin administration in adolescents with insulin-dependent diabetes mellitus","volume":"256","author":"Orr","year":"1986","journal-title":"JAMA"},{"key":"10.1111\/pedi.12650-BIB0025|pedi12650-cit-0025","first-page":"28","article-title":"Surreptitious insulin administration","volume":"141","author":"Brouhard","year":"1987","journal-title":"Am J Dis Child"},{"key":"10.1111\/pedi.12650-BIB0026|pedi12650-cit-0026","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/00000441-199211000-00006","article-title":"Case report: factitious hypoglycemia in diabetic patients","volume":"304","author":"Sheehy","year":"1992","journal-title":"Am J Med Sci"},{"key":"10.1111\/pedi.12650-BIB0027|pedi12650-cit-0027","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/BF01955200","article-title":"Insulin abuse in an adolescent with insulin-dependent diabetes mellitus","volume":"155","author":"Scaramuzza","year":"1996","journal-title":"Eur J Pediatr"},{"key":"10.1111\/pedi.12650-BIB0028|pedi12650-cit-0028","first-page":"259","article-title":"Pediatric management problems. Infectious mononucleosis","volume":"28","author":"Belkengren","year":"2002","journal-title":"Pediatr Nurs"},{"key":"10.1111\/pedi.12650-BIB0029|pedi12650-cit-0029","doi-asserted-by":"crossref","first-page":"430","DOI":"10.2337\/diacare.29.02.06.dc05-1845","article-title":"Recurrent comas due to secret self-administration of insulin in adolescents with type 1 diabetes","volume":"29","author":"Boileau","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1111\/pedi.12650-BIB0030|pedi12650-cit-0030","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1399-5448.2007.00295.x","article-title":"Unexplained hypoglycaemia on a pump","volume":"8","author":"Franklin","year":"2007","journal-title":"Pediatr Diabetes"},{"key":"10.1111\/pedi.12650-BIB0031|pedi12650-cit-0031","doi-asserted-by":"crossref","first-page":"258","DOI":"10.4088\/PCC.09r00802","article-title":"Insulin overdose among patients with diabetes: a readily available means of suicide","volume":"11","author":"Russell","year":"2009","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"10.1111\/pedi.12650-BIB0032|pedi12650-cit-0032","doi-asserted-by":"crossref","first-page":"e1246","DOI":"10.1542\/peds.2009-1830","article-title":"Prime-time hypoglycemia: factitious hypoglycemia during insulin-pump therapy","volume":"125","author":"Osipoff","year":"2010","journal-title":"Pediatrics"},{"key":"10.1111\/pedi.12650-BIB0033|pedi12650-cit-0033","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1464-5491.2011.03263.x","article-title":"Factitious self-manipulation of the external insulin pump in adolescents with type 1 diabetes","volume":"28","author":"Moreau","year":"2011","journal-title":"Diabet Med"},{"key":"10.1111\/pedi.12650-BIB0034|pedi12650-cit-0034","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s13312-015-0701-3","article-title":"Surreptitious insulin overdosing in adolescents with type 1 diabetes","volume":"52","author":"Jain","year":"2015","journal-title":"Indian Pediatr"},{"key":"10.1111\/pedi.12650-BIB0035|pedi12650-cit-0035","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1210\/jc.2016-1971","article-title":"Factitious Graves\u2019 disease due to biotin immunoassay interference-a case and review of the literature","volume":"101","author":"Elston","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/pedi.12650-BIB0036|pedi12650-cit-0036","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1176\/appi.psy.48.1.60","article-title":"Frequency of ICD-10 factitious disorder: survey of senior hospital consultants and physicians in private practice","volume":"48","author":"Fliege","year":"2007","journal-title":"Psychosomatics"},{"key":"10.1111\/pedi.12650-BIB0037|pedi12650-cit-0037","first-page":"3573","article-title":"Factitious Cushing syndrome","volume":"81","author":"Cizza","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1111\/pedi.12650-BIB0038|pedi12650-cit-0038","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1176\/appi.psy.49.5.392","article-title":"Factitious disorder in children and adolescents: a retrospective study","volume":"49","author":"Ehrlich","year":"2008","journal-title":"Psychosomatics"},{"key":"10.1111\/pedi.12650-BIB0039|pedi12650-cit-0039","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/1367493512462262","article-title":"Factitious disorders and Munchausen syndrome: the tip of the iceberg","volume":"17","author":"Ferrara","year":"2013","journal-title":"J Child Health Care"},{"key":"10.1111\/pedi.12650-BIB0040|pedi12650-cit-0040","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1001\/archinte.1993.00410050082011","article-title":"The molar ratio of insulin to C-peptide. An aid to the diagnosis of hypoglycemia due to surreptitious (or inadvertent) insulin administration","volume":"153","author":"Lebowitz","year":"1993","journal-title":"Arch Intern Med"},{"key":"10.1111\/pedi.12650-BIB0041|pedi12650-cit-0041","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jadohealth.2013.07.024","article-title":"Suicidal thoughts and attempts among U.S. High school students: trends and associated health-risk behaviors, 1991-2011","volume":"54","author":"Lowry","year":"2014","journal-title":"J Adolesc Health"},{"key":"10.1111\/pedi.12650-BIB0042|pedi12650-cit-0042","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1136\/bmj.319.7222.1417","article-title":"Insulin as a substance of misuse in a patient with insulin dependent diabetes mellitus","volume":"319","author":"Cassidy","year":"1999","journal-title":"BMJ"},{"key":"10.1111\/pedi.12650-BIB0043|pedi12650-cit-0043","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2337\/dc06-0087","article-title":"Depressive symptoms in children and adolescents with type 1 diabetes: association with diabetes-specific characteristics","volume":"29","author":"Hood","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1111\/pedi.12650-BIB0044|pedi12650-cit-0044","first-page":"1528","article-title":"Suicidal ideation and behavior and noncompliance with the medical regimen among diabetic adolescents","volume":"36","author":"Goldston","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1111\/pedi.12650-BIB0045|pedi12650-cit-0045","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1542\/peds.81.4.526","article-title":"Attempted suicide by insulin overdose in insulin-dependent diabetic adolescents","volume":"81","author":"Kaminer","year":"1988","journal-title":"Pediatrics"},{"key":"10.1111\/pedi.12650-BIB0046|pedi12650-cit-0046","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0033-3182(89)72313-6","article-title":"Insulin misuse: a review of an overlooked psychiatric problem","volume":"30","author":"Kaminer","year":"1989","journal-title":"Psychosomatics"},{"key":"10.1111\/pedi.12650-BIB0047|pedi12650-cit-0047","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1136\/archdischild-2016-312581","article-title":"Excess all-cause mortality before age 30 in childhood onset type 1 diabetes: data from the Brecon Group Cohort in Wales","volume":"103","author":"Wasag","year":"2018","journal-title":"Arch Dis Child"},{"key":"10.1111\/pedi.12650-BIB0048|pedi12650-cit-0048","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2337\/dc06-0087","article-title":"Depressive symptoms in children and adolescents with type 1 diabetes: association with diabetes-specific characteristics","volume":"29","author":"Hood","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1111\/pedi.12650-BIB0049|pedi12650-cit-0049","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0145-2134(03)00030-9","article-title":"The deceit continues: an updated literature review of Munchausen syndrome by proxy","volume":"27","author":"Sheridan","year":"2003","journal-title":"Child Abuse Negl"},{"key":"10.1111\/pedi.12650-BIB0050|pedi12650-cit-0050","doi-asserted-by":"crossref","first-page":"240","DOI":"10.7326\/0003-4819-99-2-240","article-title":"Factitious disorders in a teaching hospital","volume":"99","author":"Reich","year":"1983","journal-title":"Ann Intern Med"},{"key":"10.1111\/pedi.12650-BIB0051|pedi12650-cit-0051","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.psyneuen.2016.04.019","article-title":"Symptoms of depression and anxiety in youth with type 1 diabetes: a systematic review and meta-analysis","volume":"70","author":"Buchberger","year":"2016","journal-title":"Psychoneuroendocrinology"}],"container-title":["Pediatric Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpedi.12650","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/pedi.12650\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T18:10:33Z","timestamp":1671819033000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pedi.12650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,6]]}},"URL":"https:\/\/doi.org\/10.1111\/pedi.12650","archive":["Portico"],"relation":{},"ISSN":["1399-543X"],"issn-type":[{"value":"1399-543X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2,21]]}}}