{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:02:41Z","timestamp":1788397361013,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T00:00:00Z","timestamp":1353542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>p<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>, under mono\u2010 and infratherapeutic calcineurin inhibition, may constitute an optimal condition combining graft acceptance with low <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content> load and minimal <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>\u2010related toxicity. We reviewed 171 pediatric (&lt;15.0\u00a0yr) survivors beyond one\u00a0yr after <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>, transplanted between April 1999 and June 2007 under tacrolimus\u2010based regimens (median follow\u2010up post\u2010<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>: 6.0\u00a0yr, range: 0.8\u20139.5\u00a0yr). Their current status regarding <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content> therapy was analyzed and correlated with initial immunoprophylaxis. p<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> was defined as tacrolimus monotherapy, with mean trough blood levels &lt;4\u00a0ng\/mL during the preceding year of follow\u2010up, combined with normal liver function tests. The 66 children transplanted before April 2001 received a standard tacrolimus\u2013steroid regimen. Beyond April 2001, 105 patients received steroid\u2010free tacrolimus\u2013basiliximab or tacrolimus\u2013daclizumab immunoprophylaxis. In the latter group, 43 (41%) never experienced any acute rejection episode and never received steroids. In the long term, a total of 79 recipients (47%) developed p<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> (n\u00a0=\u00a073) or <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>\u2010free operational tolerance (n\u00a0=\u00a06), 27 of them belonging to the 43 steroid\u2010free patients (63%). In contrast, only 52\/128 (41%) children treated with steroids subsequently developed prope\/operational tolerance (p\u00a0=\u00a00.012). Steroid\u2010free tacrolimus\u2010based <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content> seems to promote long\u2010term graft acceptance under minimal\/no <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>. These results constitute the first evidence that minimization of <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content>, including steroid avoidance, might be tolerogenic in the long term after pediatric <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.12024","type":"journal-article","created":{"date-parts":[[2012,11,22]],"date-time":"2012-11-22T09:33:18Z","timestamp":1353576798000},"page":"59-64","source":"Crossref","is-referenced-by-count":17,"title":["<i>Prope<\/i> tolerance after pediatric liver transplantation"],"prefix":"10.1111","volume":"17","author":[{"given":"Christophe","family":"Bourdeaux","sequence":"first","affiliation":[{"name":"Pediatric Surgery and Transplant Unit Saint\u2010Luc University Clinics Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Pire","sequence":"additional","affiliation":[{"name":"Pediatric Surgery and Transplant Unit Saint\u2010Luc University Clinics Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Janssen","sequence":"additional","affiliation":[{"name":"Pediatric Surgery and Transplant Unit Saint\u2010Luc University Clinics Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"St\u00e9phenne","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Saint\u2010Luc University Clinics Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Smets","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Saint\u2010Luc University Clinics Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Sokal","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Unit Saint\u2010Luc University Clinics Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"de Magn\u00e9e","sequence":"additional","affiliation":[{"name":"Pediatric Surgery and Transplant Unit Saint\u2010Luc University Clinics Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Fusaro","sequence":"additional","affiliation":[{"name":"Pediatric Surgery and Transplant Unit Saint\u2010Luc University Clinics Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Reding","sequence":"additional","affiliation":[{"name":"Pediatric Surgery and Transplant Unit Saint\u2010Luc University Clinics Universit\u00e9 Catholique de Louvain Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)77739-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)01441-9"},{"key":"e_1_2_10_4_1","first-page":"176","article-title":"The pediatric liver transplantation program at the Universit\u00e9 Catholique de Louvain","volume":"67","author":"Reding R","year":"2004","journal-title":"Acta Gastroenterol 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