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Recent studies have reported the efficiency of <jats:styled-content style=\"fixed-case\">HOT<\/jats:styled-content> in adult patients who underwent allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, but data in children are scarce. We report our single center experience with <jats:styled-content style=\"fixed-case\">HOT<\/jats:styled-content> in late\u2010onset <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. Treatment with <jats:styled-content style=\"fixed-case\">HOT<\/jats:styled-content> consisted of daily sessions of breathing 100% O<jats:sub>2<\/jats:sub> for a total of 75\u00a0min in the hyperbaric chamber with a minimum of eight sessions. <jats:styled-content style=\"fixed-case\">HOT<\/jats:styled-content> had been associated with a concomitant treatment with oral oxybutynin, hyperhydration and\/or irrigation of the bladder through the catheter. Cidofovir had been administered based on the demonstration of viral infection. Between 2004 and 2011, 10 patients developed severe <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> after a median of 26\u00a0days after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HOT<\/jats:styled-content> was started after a median of six days since the clinical diagnosis of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>. After a median of 10 sessions of <jats:styled-content style=\"fixed-case\">HOT<\/jats:styled-content>, seven of 10 patients were in complete remission. <jats:styled-content style=\"fixed-case\">HOT<\/jats:styled-content> is a well\u2010tolerated procedure also in the pediatric setting. The early start of <jats:styled-content style=\"fixed-case\">HOT<\/jats:styled-content> might be effective in the treatment of <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> offering advantages in terms of duration of symptoms and hospitalization.<\/jats:p>","DOI":"10.1111\/petr.12031","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T07:14:12Z","timestamp":1355296452000},"page":"86-91","source":"Crossref","is-referenced-by-count":25,"title":["Clinical effectiveness of early treatment with hyperbaric oxygen therapy for severe late\u2010onset hemorrhagic cystitis after hematopoietic stem cell transplantation in pediatric patients"],"prefix":"10.1111","volume":"17","author":[{"given":"Daniele","family":"Zama","sequence":"first","affiliation":[{"name":"Pediatric Oncology and Hematology Unit \u201cLalla Ser\u00e0gnoli\u201d Departement of Pediatrics University of Bologna Sant'Orsola\u2010Malpighi Hospital Bologna 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