{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:52:41Z","timestamp":1787237561526,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recipient parenchymal lymphatic cells are crucial for direct and indirect pathways of allorecognition. We proposed that alemtuzumab, being infused several weeks pretransplant could eradicate peripheral lymphatic cells and promote donor\u2010specific tolerance. We present here a single center, retrospective review of 101 consecutive living\u2010donor kidney transplantations to pediatric patients aged from seven\u00a0month to 18\u00a0yr, performed between\n                    <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                    eptember 2006 and\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    pril 2010. Immunosupression protocol included two 30\u00a0mg doses of alemtuzumab: first given 12\u201329\u00a0d prior to transplantation and second at the time of transplantation. Maintenance immunosupression was based on combination of low dose and wide range\n                    <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\n                    and mycophenolate. Patients were followed for 3.8\u00a0\u00b1\u00a01.4\u00a0yr and protocol biopsies were taken one\u00a0month, one, and three\u00a0yr post transplant. The\n                    <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\n                    aplan\u2013\n                    <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>\n                    eier graft and patient survival was 96% and 97% for one\u00a0yr, 89% and 93% for three\u00a0yr. Biopsy proven acute rejection developed in 26% patients at one\u00a0yr and in 35% at two\u00a0yr, no rejections occurred beyond two\u00a0yr. We conclude that alemtuzumab pretreatment prior to living related donor kidney transplantation allows to reach satisfactory middle\u2010term results in pediatric patients with wide range and low\n                    <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content>\n                    concentrations.\n                  <\/jats:p>","DOI":"10.1111\/petr.12048","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T21:52:19Z","timestamp":1361915539000},"page":"168-178","source":"Crossref","is-referenced-by-count":45,"title":["Alemtuzumab induction in pediatric kidney transplantation"],"prefix":"10.1111","volume":"17","author":[{"given":"Michael M.","family":"Kaabak","sequence":"first","affiliation":[{"name":"Organ Transplant Division Russian Scientific Center of Surgery Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezda N.","family":"Babenko","sequence":"additional","affiliation":[{"name":"Kidney Transplant Department Russian Scientific Center of Surgery Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry V.","family":"Samsonov","sequence":"additional","affiliation":[{"name":"New York Medical College Valhalla NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery A.","family":"Sandrikov","sequence":"additional","affiliation":[{"name":"Diagnostic Division Russian Scientific Center for Surgery Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey A.","family":"Maschan","sequence":"additional","affiliation":[{"name":"Federal Clinical Research Center for Pediatric Hematology, Oncology and Immunology Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan K.","family":"Zokoev","sequence":"additional","affiliation":[{"name":"Kidney Transplant Department Russian Scientific Center of Surgery Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200011000-00010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1093"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000071362.99021.D9"},{"key":"e_1_2_8_5_1","first-page":"1394","article-title":"Remission induction in non\u2010Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH\u20101H","volume":"2","author":"Hale G","year":"1998","journal-title":"Lancet"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2006.09.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/S0140-6736(05)77739-4","article-title":"Prope tolerance, perioperative Campath 1H, and low\u2010dose cyclosporine monotherapy in renal allograft recipients","volume":"351","author":"Calne R","year":"1998","journal-title":"Lancet"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00822.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02492.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009546"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31822ca7ca"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e328348b44c"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00879.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.01.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181903da7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01116.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050085"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1681\/ASN.V84647","article-title":"Prediction of cyclosporine area under the curve using a three\u2010point sampling strategy after Neoral administration","volume":"8","author":"Gaspari F","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2011.01640.x"},{"key":"e_1_2_8_20_1","unstructured":"NAPRTCS.Annual Transplant Report 2010. 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