{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:01:10Z","timestamp":1763017270070},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>PE<\/jats:styled-content>can occur followingHCT<\/jats:styled-content>. However, the incidence, etiology, risk factors, and treatment remain unclear. We performed a retrospective study evaluating 355 pediatric recipients ofHCT<\/jats:styled-content>treated at a single institution between January 2005 and August 2010. No cases ofPE<\/jats:styled-content>were identified in the autologousHCT<\/jats:styled-content>(auto\u2010HCT<\/jats:styled-content>) recipients (0\/43), while 19% (57\/296) of allogeneicHCT<\/jats:styled-content>(allo\u2010HCT<\/jats:styled-content>) developedPE<\/jats:styled-content>. Among the 57PE<\/jats:styled-content>patients, 40 (70%) were males; the median age at transplantation was 6.6\u00a0yr (0.1\u201317.3\u00a0yr). Thirty\u2010six patients (63%) had significantPE<\/jats:styled-content>with 23 patients (40%) treated by pericardiocentesis, and 19 (33%) experiencing recurrentPE<\/jats:styled-content>.OS<\/jats:styled-content>rates for patients who developedPE<\/jats:styled-content>were 84% at 100\u00a0days and 65% at three\u00a0yr afterHCT<\/jats:styled-content>. Risk factors associated withPE<\/jats:styled-content>on multivariate analysis included myeloablative conditioning (p\u00a0=\u00a00.01), delayed neutrophil engraftment (p\u00a0<\u00a00.01), andCMV<\/jats:styled-content>\u00a0+\u00a0serostatus of the recipient (p\u00a0=\u00a00.03). Recipients with non\u2010malignant diseases were significantly less likely to die after development ofPE<\/jats:styled-content>(p\u00a0=\u00a00.02 and 0.004 when comparing with standard and high\u2010risk diseases, respectively). In summary,PE<\/jats:styled-content>is a common and significant complication of pediatric allo\u2010HCT<\/jats:styled-content>. Prospective studies are needed to better determine the etiology and optimal method ofPE<\/jats:styled-content>treatment afterHCT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/petr.12062","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T04:12:59Z","timestamp":1362629579000},"page":"294-299","source":"Crossref","is-referenced-by-count":30,"title":["Pericardial effusion after pediatric hematopoietic cell transplant"],"prefix":"10.1111","volume":"17","author":[{"given":"Osamah","family":"Aldoss","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics University of Minnesota Amplatz Children's Hospital Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Gruenstein","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics University of Minnesota Amplatz Children's Hospital Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Bass","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics University of Minnesota Amplatz Children's Hospital Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Steinberger","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics University of Minnesota Amplatz Children's Hospital Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Core Masonic Cancer Center University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd E.","family":"DeFor","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Core Masonic Cancer Center University of Minnesota Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Tolar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Blood and Marrow Transplant Department of Pediatrics University of Minnesota Amplatz Children's Hospital Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Verneris","sequence":"additional","affiliation":[{"name":"Division of Pediatric Blood and Marrow Transplant Department of Pediatrics University of Minnesota Amplatz Children's Hospital Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Orchard","sequence":"additional","affiliation":[{"name":"Division of Pediatric Blood and Marrow Transplant Department of Pediatrics University of Minnesota Amplatz Children's Hospital Minneapolis MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705992"},{"key":"e_1_2_8_3_1","first-page":"213","article-title":"Pericardial effusion following conditioning for bone marrow transplantation in acute leukaemia","volume":"2","author":"Veys PA","year":"1987","journal-title":"Bone Marrow 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