{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:17:02Z","timestamp":1760955422661},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,14]],"date-time":"2013-04-14T00:00:00Z","timestamp":1365897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rejection with acute hemodynamic compromise after <jats:styled-content style=\"fixed-case\">OHT<\/jats:styled-content> is rare in children, and is associated with poor survival. We retrospectively reviewed the management, course and outcome of recipients with late (following initial hospital discharge) rejection with acute hemodynamic compromise who were supported on <jats:styled-content style=\"fixed-case\">ECLS<\/jats:styled-content>. Of 197 consecutive children undergoing <jats:styled-content style=\"fixed-case\">OHT<\/jats:styled-content> (84 male; mean [SD] age 8.3 [5.7] [range 0.1\u201318.8\u00a0yr]) between 2\/2002 and 10\/2012, 187 children survived and were discharged from hospital. Mean (SD) follow\u2010up was 5.0 (3.1) (range 0.1\u201310.6) yr. During follow\u2010up, seven presented with severe hemodynamic compromise after transplantation (of whom one patient had been transplanted elsewhere). All seven children, who presented in hemodynamic collapse with poor cardiac function refractory to inotropic support, were placed on <jats:styled-content style=\"fixed-case\">ECLS<\/jats:styled-content>\u2014two following in\u2010hospital cardiac arrest. The median duration of <jats:styled-content style=\"fixed-case\">ECLS<\/jats:styled-content> was 6 (range 5\u201315) days. All survived to decannulation, with one death from overwhelming sepsis 20\u00a0days after presentation. The median (range) duration (in days) of inotropic requirement post <jats:styled-content style=\"fixed-case\">ECLS<\/jats:styled-content> was 11 (5\u201327), the median ventilation time was 8 (7\u201330), median <jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content> length of stay was 14 (10\u201354), and median hospitalization was 24 (19\u2013118). In all, ventricular function normalized (<jats:styled-content style=\"fixed-case\">FS<\/jats:styled-content> &gt;28%) within 10 (7\u201322) days. There was significant short\u2010term morbidity; however, over a median follow\u2010up of 5.9 (range 0.7\u20139.2) yr, all survivors have good functional status with no significant apparent neurological sequelae. <jats:styled-content style=\"fixed-case\">ECLS<\/jats:styled-content> thus appears to be a good rescue therapy for children with severe acute rejection post <jats:styled-content style=\"fixed-case\">OHT<\/jats:styled-content>, refractory to conventional treatment, leading to good medium\u2010term outcome.<\/jats:p>","DOI":"10.1111\/petr.12078","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T02:20:42Z","timestamp":1365992442000},"page":"336-342","source":"Crossref","is-referenced-by-count":1,"title":["ECLS for children with late (post\u2010discharge) rejection after heart transplantation"],"prefix":"10.1111","volume":"17","author":[{"given":"Astrid E.","family":"Lammers","sequence":"first","affiliation":[{"name":"Department of Paediatric Cardiology Great Ormond Street Hospital for Children NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Burch","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiology Great Ormond Street Hospital for Children NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Cardiac Critical Care Great Ormond Street Hospital for Children NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan A.","family":"Hoschtitzky","sequence":"additional","affiliation":[{"name":"Department of Paediatric Cardiac Surgery Great Ormond Street Hospital for Children NHS Foundation Trust London 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