{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:13Z","timestamp":1761986473210},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> can be curative for many <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>. Little is known about the outcome of <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for patients with <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> in the developing countries. We retrospectively reviewed all children with <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> who received <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> at <jats:styled-content style=\"fixed-case\">KHCC<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ordan between <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 2003 and <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>ctober 2011. Twenty\u2010eight patients were identified. The median age was 16\u00a0months (3\u00a0months\u201317\u00a0yr). Patients' diagnoses were <jats:styled-content style=\"fixed-case\">SCID<\/jats:styled-content> (n\u00a0=\u00a016), <jats:styled-content style=\"fixed-case\">CHS<\/jats:styled-content> (n\u00a0=\u00a03), <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content> (n\u00a0=\u00a03), <jats:styled-content style=\"fixed-case\">WAS<\/jats:styled-content> (n\u00a0=\u00a02), <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>riscelli syndrome (n\u00a0=\u00a01), <jats:styled-content style=\"fixed-case\">ALPS<\/jats:styled-content> (n\u00a0=\u00a01), <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>menn's syndrome (n\u00a0=\u00a01), and DiGeorge syndrome (n\u00a0=\u00a01). Seventeen patients received <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010matched related <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, eight received maternal un\u2010manipulated haploidentical <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, and three received unrelated cord blood transplantation. Nine patients (32%) developed <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content>osis secondary to reactivation of pretransplant vaccination. Three died while still receiving anti\u2010tuberculosis drugs, one still on treatment, and all others have recovered. Six patients had graft failure; four of them received no conditioning regimens. At a median follow up of 32\u00a0months (range 1\u201067), 21 patients are alive, with overall survival of 72%. We conclude that <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> patients can be performed with a good outcome in developing countries; however, delayed diagnosis or referral and <jats:styled-content style=\"fixed-case\">BCG<\/jats:styled-content> reactivation are unique challenges.<\/jats:p>","DOI":"10.1111\/petr.12081","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T03:30:20Z","timestamp":1369107020000},"page":"394-402","source":"Crossref","is-referenced-by-count":24,"title":["Hematopoietic stem cell transplantation for children with primary immunodeficiency diseases: Single center experience in Jordan"],"prefix":"10.1111","volume":"17","author":[{"given":"Nisreen","family":"Amayiri","sequence":"first","affiliation":[{"name":"Department of Pediatrics KHCC Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulhadi","family":"Al\u2010Zaben","sequence":"additional","affiliation":[{"name":"Bone Marrow and Stem Cell Transplantation Program King Hussein Cancer Center Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubna","family":"Ghatasheh","sequence":"additional","affiliation":[{"name":"Bone Marrow and Stem Cell Transplantation Program King Hussein Cancer Center Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haydar","family":"Frangoul","sequence":"additional","affiliation":[{"name":"Pediatric Stem Cell Transplant Program Monroe Carell Jr. Children's Hospital at Vanderbilt Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayad Ahmed","family":"Hussein","sequence":"additional","affiliation":[{"name":"Bone Marrow and Stem Cell Transplantation Program King Hussein Cancer Center Amman 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