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We reported a patient who received two courses of bortezomib for the treatment of an acute <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> associated with de novo <jats:styled-content style=\"fixed-case\">HLA DSA<\/jats:styled-content> that occurred 18\u00a0months after renal transplantation because of non\u2010compliance. Graft biopsy revealed features of acute humoral rejection with plasmocyte infiltration and C4d staining. Bortezomib was associated with corticosteroid pulses, <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>gs, and <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>. Despite this rapid management, the patient lost his graft and carried on dialysis. Bortezomib therapy in addition to current therapy of <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> is not always effective in the treatment for late acute <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content> in renal transplantation. We discuss on the place of such a treatment and other therapeutic strategies in this indication.<\/jats:p>","DOI":"10.1111\/petr.12113","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T12:11:07Z","timestamp":1373371867000},"source":"Crossref","is-referenced-by-count":10,"title":["Failure of bortezomib to cure acute antibody\u2010mediated rejection in a non\u2010compliant renal transplant patient"],"prefix":"10.1111","volume":"17","author":[{"given":"A.","family":"Ryckewaert","sequence":"first","affiliation":[{"name":"Pediatric Department Centre Hospitalier et Universitaire Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Allain\u2010Launay","sequence":"additional","affiliation":[{"name":"Pediatric Department Centre Hospitalier et Universitaire Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Moreau","sequence":"additional","affiliation":[{"name":"Histopathology 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