{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:56:29Z","timestamp":1783630589124,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of non\u2010invasive markers to diagnose liver allograft fibrosis is not well established in children after LTx. TE, FT, and ELF score were performed in 117 liver\u2010transplanted children (60M, 8.9 [0.5\u201318.5]\u00a0yr) and 336 healthy controls. Liver biopsy was available in 36 children. Results of histology and non\u2010invasive markers were compared using correlation coefficient or Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test as appropriate. TE correlated best with histological degree of fibrosis (r\u00a0=\u00a00.85 vs. r\u00a0=\u00a00.04 [FT] or r\u00a0=\u00a0\u22120.38 [ELF]). Liver stiffness values for transplanted children without fibrosis were significantly higher than those of healthy controls (7.55 [5.4\u201320.4]\u00a0kPa vs. 4.5 [2.5\u20138.9]\u00a0kPa). Presence of rejection was a potent confounder for the performance of TE. Both TE and FT reflected clinical changes (acute rejection, cholestasis, increasing fibrosis) in a total of 16 patients who underwent serial measurements. TE correlates better with histological degree of fibrosis in liver\u2010transplanted children than FT or ELF, but an individual baseline value needs to be determined for each patient. Normal or cutoff values for pathological degrees of fibrosis cannot be transferred from non\u2010transplanted children. Follow\u2010up studies, preferably with protocol biopsies, might help to improve the diagnostic quality of TE.<\/jats:p>","DOI":"10.1111\/petr.12116","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T07:37:05Z","timestamp":1372318625000},"page":"525-534","source":"Crossref","is-referenced-by-count":47,"title":["The use of transient elastography and non\u2010invasive serum markers of fibrosis in pediatric liver transplant recipients"],"prefix":"10.1111","volume":"17","author":[{"given":"Imeke","family":"Goldschmidt","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Department for Pediatric Kidney, Liver and Metabolic Diseases Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Stieghorst","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Department for Pediatric Kidney, Liver and Metabolic Diseases 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Baumann","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Department for Pediatric Kidney, Liver and Metabolic Diseases Hannover Medical School Hannover 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