{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T18:18:45Z","timestamp":1775585925545,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T00:00:00Z","timestamp":1377043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin D deficiency and insufficiency are increasingly recognized in the general population, including healthy children. There is also an increasing emphasis on the importance of vitamin D status following pediatric liver transplantation and specifically its relationship to metabolic bone disease and growth retardation. Vitamin D insufficiency has also been associated with multiple immunological and metabolic disorders in adults. To our knowledge, this has not been systematically evaluated in children undergoing liver transplantation to date. Between October 2004 and August 2008, serum 25\u2010(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)\u2010vitamin D levels were measured in 199 children who had undergone liver transplantation at Birmingham Children's Hospital. Potential factors contributing to vitamin D levels were evaluated. Additionally, we evaluated a possible relationship between vitamin D levels and immunological phenomena and metabolic complications. Median 25\u2010(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)\u2010vitamin D level was 19.5\u00a0ng\/mL (range: 4.4\u201371.4\u00a0ng\/mL). A total of 105 children (53%) had insufficient vitamin D levels and 28 children (14%) showed vitamin D deficiency. The only factors found to be associated with vitamin D deficiency were season of sample, ethnicity, and <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> levels. Vitamin D deficiency was more prevalent during the first year after transplantation. We did not find a significant relationship between vitamin D levels and graft function or any other immunological and metabolic complications. Vitamin D insufficiency and deficiency are common in children after liver transplantation, especially in winter and spring and in non\u2010white patients. Initial post\u2010transplant period and high <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> are significantly associated with vitamin D deficiency. Vitamin D status should be monitored following pediatric liver transplantation and vitamin D supplementation provided as required.<\/jats:p>","DOI":"10.1111\/petr.12135","type":"journal-article","created":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T05:55:45Z","timestamp":1377064545000},"page":"631-637","source":"Crossref","is-referenced-by-count":17,"title":["Vitamin D deficiency and insufficiency after pediatric liver transplantation"],"prefix":"10.1111","volume":"17","author":[{"given":"Maria","family":"Legarda","sequence":"first","affiliation":[{"name":"Liver Unit Birmingham Children's Hospital Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Gordon","sequence":"additional","affiliation":[{"name":"Liver Unit Birmingham Children's Hospital Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Liver Unit Birmingham Children's Hospital 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