{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:37:09Z","timestamp":1790753829839,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adjusted survival outcomes following hepatic resection and transplantation for pediatric liver tumors have not been compared. To address this question, we conducted a retrospective cohort study using the <jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content> registry. While <jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content> lacks certain specifics regarding staging, chemotherapy, comorbidities, and recurrence, important hypothesis\u2010generating data are available and were analyzed using <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier statistics and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox proportional hazards regression. All <jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content> patients under the age of 20\u00a0yr undergoing surgery for <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content> (n\u00a0=\u00a0318) or <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> (n\u00a0=\u00a080) between 1998 and 2009 were included. Of <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content> patients, 83.3% underwent resection and 16.7% transplantation. Advanced disease, vascular invasion, and satellite lesions were more common among transplant patients. Unadjusted five\u2010yr survival was equivalent, as was the adjusted hazard of death for transplant relative to resection (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a00.58, p\u00a0=\u00a00.63). Of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients, 75.0% underwent resection and 25.0% transplantation. Transplant patients had a higher prevalence of vascular invasion and satellite lesions. Five\u2010yr survival was 53.4% after resection and 85.3% after transplant, and the adjusted hazard of death was significantly lower after transplantation (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a00.05, p\u00a0=\u00a00.045). While transplantation is generally reserved for unresectable tumors, the favorable survival seen in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients suggests that liberalized transplant criteria might improve survival, although further prospective data are needed.<\/jats:p>","DOI":"10.1111\/petr.12144","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T04:39:51Z","timestamp":1378096791000},"page":"744-750","source":"Crossref","is-referenced-by-count":74,"title":["Surgical treatment of primary liver tumors in children: Outcomes analysis of resection and transplantation in the <scp>SEER<\/scp> database"],"prefix":"10.1111","volume":"17","author":[{"given":"Jarod P.","family":"McAteer","sequence":"first","affiliation":[{"name":"Division of Pediatric General and Thoracic Surgery Seattle Children's Hospital Seattle WA USA"},{"name":"Department of Surgery University of Washington School of Medicine Seattle WA 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