{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T19:10:03Z","timestamp":1760987403539,"version":"3.40.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CHL<\/jats:styled-content>type is the least common major form of<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010related<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>but rarely occurs in pediatric recipients; development of<jats:styled-content style=\"fixed-case\">CHL<\/jats:styled-content>subsequent to other<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>subtypes in the same transplant recipient is even more unusual. Because of its rarity, indications on the best treatment strategy are limited. Patients have been mostly treated with standard<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>chemotherapy\/radiotherapy, and prognosis seems more favorable than other monomorphic<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>s. Herein, we describe a pediatric case of<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010associated, stage<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010B,<jats:styled-content style=\"fixed-case\">CHL<\/jats:styled-content>arising in a heart allograft recipient eight\u00a0yr after diagnosis of B\u2010cell polymorphic<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>. The patient was successfully treated with adjusted\u2010dose<jats:styled-content style=\"fixed-case\">HL<\/jats:styled-content>chemotherapy and autologous<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010specific CTL, without discontinuation of maintenance immunosuppression. At two\u00a0yr from therapy completion, the patient is in CR with stable organ function. With this strategy, it may be possible to reproduce the good prognostic data reported for<jats:styled-content style=\"fixed-case\">CHL<\/jats:styled-content>\u2010type<jats:styled-content style=\"fixed-case\">PTLD<\/jats:styled-content>, with decreased risk of organ toxicity or rejection.<\/jats:p>","DOI":"10.1111\/petr.12146","type":"journal-article","created":{"date-parts":[[2013,9,2]],"date-time":"2013-09-02T04:40:26Z","timestamp":1378096826000},"source":"Crossref","is-referenced-by-count":12,"title":["Successful treatment of a classic Hodgkin lymphoma\u2010type post\u2010transplant lymphoproliferative disorder with tailored chemotherapy and Epstein\u2013Barr virus\u2010specific cytotoxic T lymphocytes in a pediatric heart transplant recipient"],"prefix":"10.1111","volume":"17","author":[{"given":"Sabrina","family":"Basso","sequence":"first","affiliation":[{"name":"Pediatric Hematology\/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zecca","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Calafiore","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rubert","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Fiocchi","sequence":"additional","affiliation":[{"name":"Heart Transplant Center Ospedali Riuniti Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Paulli","sequence":"additional","affiliation":[{"name":"Pathology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Quartuccio","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Guido","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Sebastiani","sequence":"additional","affiliation":[{"name":"Heart Transplant Center Ospedali Riuniti Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio Alberto","family":"Croci","sequence":"additional","affiliation":[{"name":"Pathology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Beschi","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Nardiello","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Ginevri","sequence":"additional","affiliation":[{"name":"Nephrology Istituto G. Gaslini Genova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Cugno","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Comoli","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\/Oncology Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"471","volume-title":"Pediatric Solid Organ Transplantation Pediatric Clinics of North America","author":"Green M","year":"2003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1812-2"},{"key":"e_1_2_8_4_1","first-page":"173","article-title":"The pathology of posttransplant lymphoproliferative disorders occurring in the setting of cyclosporin A\u2010prednisone immunosuppression","volume":"133","author":"Nalesnik MA","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)67933-6"},{"volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2008","author":"Swerdlow SH","key":"e_1_2_8_6_1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931101)72:9<2568::AID-CNCR2820720910>3.0.CO;2-D"},{"key":"e_1_2_8_8_1","first-page":"56","article-title":"De novo malignancies in pediatric organ transplant recipients","volume":"2","author":"Penn I","year":"1998","journal-title":"Pediatr Transplant"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.2392"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.01.013"},{"key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s10024-003-9877-y","article-title":"Hodgkin\u2010like posttransplant lymphoproliferative disorder in children: Does it differ from posttransplant Hodgkin lymphoma","volume":"7","author":"Ranganathan S","year":"2004","journal-title":"Pediatr Dev Pathol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1397-3142.2003.00113.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896909338597"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.7.2592"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00854.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00913-08"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199611000-00012"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a010570"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318030c9ea"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.080068597"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200604000-00007"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.4961"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.074"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12146","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T14:20:46Z","timestamp":1746022846000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/petr.12146"],"URL":"https:\/\/doi.org\/10.1111\/petr.12146","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"type":"print","value":"1397-3142"},{"type":"electronic","value":"1399-3046"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}