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Everolimus with reduced <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> therapy has been shown to be efficacious and safe in <jats:italic>de novo<\/jats:italic> pediatric kidney transplant patients in prospective trials. Prospective and retrospective data in children converted from <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> therapy to m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> inhibition following kidney, liver, or heart transplantation suggest preservation of immunosuppressive efficacy. Good renal function has been maintained when m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> inhibitors are used <jats:italic>de novo<\/jats:italic> in children following kidney transplantation or after conversion to m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> inhibition with <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> minimization. m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> inhibition with reduced <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> exposure is associated with a low risk for developing infection in children. Growth and development do not appear to be impaired during low\u2010dose m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> inhibition, but more studies are required. No firm conclusions can be drawn as to whether m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> inhibitors should be discontinued in children requiring surgical intervention or whether m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> inhibition delays progression of hepatic fibrosis after pediatric liver transplantation. In conclusion, current evidence suggests that use of m<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> inhibitors in children undergoing solid organ transplantation is efficacious and safe, but a number of issues remain unresolved and further studies are required.<\/jats:p>","DOI":"10.1111\/petr.12147","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T14:14:52Z","timestamp":1378304092000},"page":"694-706","source":"Crossref","is-referenced-by-count":40,"title":["Growing experience with m<scp>TOR<\/scp> inhibitors in pediatric solid organ transplantation"],"prefix":"10.1111","volume":"17","author":[{"given":"R.","family":"Ganschow","sequence":"first","affiliation":[{"name":"P\u00e4diatrische Hepatologie und Lebertransplantation Universit\u00e4tsklinikum Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pape","sequence":"additional","affiliation":[{"name":"Zentrum Kinderheilkunde und Jugendmedizin Medizinische Hochschule Hannover Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sturm","sequence":"additional","affiliation":[{"name":"Kindergastroenterologie\/\u2010Hepatologie Klinik f\u00fcr Kinder\u2010 und Jugendmedizin T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Kinderkardiologie Universit\u00e4tsklinikum Gie\u00dfen Gie\u00dfen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Melter","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder\u2010 und Jugendmedizin Universit\u00e4t Regensburg Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gerner","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische Gastroenterologie\/Lebertransplantation Universit\u00e4tsklinikum Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"H\u00f6cker","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder\u2010 und Jugendmedizin Universit\u00e4tsklinikum Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Ahlenstiel","sequence":"additional","affiliation":[{"name":"Zentrum Kinderheilkunde und Jugendmedizin Medizinische Hochschule Hannover Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kemper","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Kinder\u2010 und Jugendmedizin Universit\u00e4tsklinikum Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Brinkert","sequence":"additional","affiliation":[{"name":"P\u00e4diatrische Hepatologie und Lebertransplantation Universit\u00e4tsklinikum Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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