{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T18:18:34Z","timestamp":1768673914260,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Organ availability and acceptability limit pediatric <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x. What characteristics define an unacceptable or high\u2010risk pediatric donor remains unclear. The purpose of this study was to characterize a large cohort of pediatric donors and determine the donor risk factors, including cumulative risk, that affect recipient survival. Data from the <jats:styled-content style=\"fixed-case\">PHTS<\/jats:styled-content>, a prospective multicenter study, were used to examine the impact of donor factors on the outcomes of patients listed &lt;18\u00a0yr of age who received a <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x between 1993 and 2009. Donor data were available for 3149 of 3156 <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>x (99.8%). Donor cause of death, need for inotropes, or <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content> did not affect survival outcomes (p\u00a0=\u00a00.05). Ischemic time also did not have an impact on overall recipient survival; however, longer ischemic times negatively impacted one\u2010yr post\u2010transplant survival (p\u00a0&lt;\u00a00.0001). There was no impact of cumulative risk factors on survival (p\u00a0=\u00a00.8). Although used in a minority of cases, hormonal therapy in the donor positively impacted survival (p\u00a0=\u00a00.03). In multivariate analysis, the only donor factor associated with decreased survival was smaller donor <jats:styled-content style=\"fixed-case\">BSA<\/jats:styled-content>, the other factors being related to the recipient characteristics. When analyzed by recipient age, there were no donor\u2010related factors that affected survival for those who received a transplant at &lt;6\u00a0months of age. Longer ischemic time (p\u00a0&lt;\u00a00.0001) and greater age difference between the recipient and donor (p\u00a0=\u00a00.0098) were donor\u2010related factors impacting early\u2010phase survival for recipients who received a graft at \u226510\u00a0yr of age. Factors perceived to define a marginal or high\u2010risk pediatric heart donor including inotrope use, <jats:styled-content style=\"fixed-case\">CPR<\/jats:styled-content> and donor cause of death may have less impact on outcomes than previously thought. Longer ischemic times did impact one\u00a0yr, but not overall survival, and this impact was much greater with older donors. Parameters for accepting a donor heart can potentially be expanded, especially in the infant age group, but strong consideration should always be given to the interaction between ischemic time and donor age.<\/jats:p>","DOI":"10.1111\/petr.12149","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T15:13:07Z","timestamp":1381245187000},"page":"774-781","source":"Crossref","is-referenced-by-count":70,"title":["Donors' characteristics and impact on outcomes in pediatric heart transplant recipients"],"prefix":"10.1111","volume":"17","author":[{"given":"Jennifer","family":"Conway","sequence":"first","affiliation":[{"name":"Hospital for Sick Children Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifford","family":"Chin","sequence":"additional","affiliation":[{"name":"Cincinnati's Children's Hospital Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariska","family":"Kemna","sequence":"additional","affiliation":[{"name":"Seattle Children's Hospital Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Burch","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliessa","family":"Barnes","sequence":"additional","affiliation":[{"name":"Children's Medical Center Dallas Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Tresler","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet N.","family":"Scheel","sequence":"additional","affiliation":[{"name":"Johns Hopkins Hospital Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Naftel","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Beddow","sequence":"additional","affiliation":[{"name":"Children's Hospital of New York Presbyterian New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Allain\u2010Rooney","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne I.","family":"Dipchand","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.03.090"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12237"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.08.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-005-0929-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.08.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.05.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.11.470"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70061-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000062839.58826.6D"},{"key":"e_1_2_9_11_1","unstructured":"Organ Procurement and Transplant Network.Polices: Allocation of thoracic organs. 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