{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:42:31Z","timestamp":1777448551788,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EMB<\/jats:styled-content>, the gold standard for diagnosis of <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>, poses unique risks in children. Limited cross\u2010sectional data have associated <jats:styled-content style=\"fixed-case\">LV MPI<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>. We hypothesize that a relative change in <jats:styled-content style=\"fixed-case\">MPI<\/jats:styled-content> from baseline without <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> to the time of <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> will better detect <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> than an absolute threshold <jats:styled-content style=\"fixed-case\">LV MPI<\/jats:styled-content> value. We identified 40 children with <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> \u226560\u00a0days post\u2010transplant matching them by age and time from transplantation to 40 children without <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>. There was a significant increase in <jats:styled-content style=\"fixed-case\">LV MPI<\/jats:styled-content> at time of <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> vs. baseline (0.59\u00a0\u00b1\u00a00.17 vs. 0.41\u00a0\u00b1\u00a00.11; p\u00a0&lt;\u00a00.001). There was no difference in <jats:styled-content style=\"fixed-case\">LV MPI<\/jats:styled-content> between baseline and follow\u2010up (0.41\u00a0\u00b1\u00a00.11 vs. 0.42\u00a0\u00b1\u00a00.11; p\u00a0=\u00a00.65). An absolute increase in <jats:styled-content style=\"fixed-case\">LV MPI<\/jats:styled-content> of \u22650.47 had 82.5% sensitivity and 85% specificity for <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>, whereas an increase in <jats:styled-content style=\"fixed-case\">LV MPI<\/jats:styled-content> from baseline of \u226520.4% was 90% sensitive and 100% specific. Serial measurement of <jats:styled-content style=\"fixed-case\">LV MPI<\/jats:styled-content> appears to be a sensitive and specific marker of <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">LV MPI<\/jats:styled-content> shows good interobserver agreement and increases at the time of <jats:styled-content style=\"fixed-case\">EMB<\/jats:styled-content>\u2010proven <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content> with subsequent resolution to baseline measurements upon <jats:styled-content style=\"fixed-case\">EMB<\/jats:styled-content>\u2010proven resolution of <jats:styled-content style=\"fixed-case\">ACR<\/jats:styled-content>. Future studies in larger, prospective cohorts should be undertaken to validate these findings.<\/jats:p>","DOI":"10.1111\/petr.12153","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:27:58Z","timestamp":1381541278000},"page":"782-786","source":"Crossref","is-referenced-by-count":11,"title":["Left ventricular myocardial performance index change for detection of acute cellular rejection in pediatric heart transplantation"],"prefix":"10.1111","volume":"17","author":[{"given":"Ryan","family":"Flanagan","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC Pittsburgh PA USA"},{"name":"Womack Army Medical Center Fort Bragg NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Cain","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Medical University of South Carolina Children's Hospital Charleston SC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory H.","family":"Tatum","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Duke Children's Hospital and Health Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark G.","family":"DeBrunner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey","family":"Drant","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Feingold","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Children's Hospital of Pittsburgh of UPMC Pittsburgh PA USA"},{"name":"Clinical and Translational Research University of Pittsburgh Pittsburgh PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.11.019"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00452-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00869.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.4.e40"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00559-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(99)70102-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(00)70007-1"},{"key":"e_1_2_10_9_1","first-page":"135","article-title":"New non\u2010invasive index for combined systolic and diastolic ventricular function","volume":"26","author":"Tei C","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_10_10_1","first-page":"357","article-title":"New index of combined systolic and diastolic myocardial performance: A simple and reproducible measure of cardiac function\u2013a study in normals and dilated cardiomyopathy","volume":"26","author":"Tei C","year":"1995","journal-title":"J Cardiol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.01.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00935-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2005.03.019"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2011.01530.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2010.02.011"},{"key":"e_1_2_10_16_1","unstructured":"Costa SantosC.Information based measure of disagreement on\u2010line calculator [Computer software].2012. 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