{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:11:26Z","timestamp":1779253886073,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>\n \n Cystic fibrosis (\n CF<\/jats:styled-content>\n ) is an inherited disease with a defect in epithelial chloride transport that results in a multisystem disease. Although pulmonary disease remains the primary cause of morbidity and mortality, focal biliary cirrhosis and portal hypertension may develop in up to 8% of these patients. Liver transplantation (\n TX<\/jats:styled-content>\n ) is an accepted therapy and shows good results. We report on a patient with cystic fibrosis homozygous for the most common\n CFTR<\/jats:styled-content>\n mutation delta F 508 who received a combined heterotopic liver and pancreas transplantation at the age of 18\u00a0yr. He suffered from\n CFRD<\/jats:styled-content>\n , which untypically required high doses of insulin. In addition, the patient had pulmonary complications, was chronically colonized with multiresistant\n Pseudomonas aeruginosa<\/jats:italic>\n (\n MBL<\/jats:styled-content>\n ) and had an allergic bronchopulmonary aspergillosis (\n ABPA<\/jats:styled-content>\n ). The patient remained in stable health for 54 months post\u2010\n TX<\/jats:styled-content>\n and was able to live a nearly normal life. With a follow\u2010up of five\u00a0yr, the function of the liver and pancreas allografts was excellent. However, and sadly, his pulmonary function continued to deteriorate from progression of his\n CF<\/jats:styled-content>\n , and he died of respiratory failure due to a severe pneumonia and septicemia at the age of 23\u00a0yr and five\u00a0months.\n <\/jats:p>","DOI":"10.1111\/petr.12157","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T01:12:55Z","timestamp":1382058775000},"source":"Crossref","is-referenced-by-count":13,"title":["Combined heterotopic liver\u2013pancreas transplantation as a curative treatment for liver cirrhosis and diabetes mellitus in cystic fibrosis"],"prefix":"10.1111","volume":"18","author":[{"given":"Constance","family":"Henn","sequence":"first","affiliation":[{"name":"Department of Women and Child Health Hospital for Children and Adolescents University Hospital Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kapellen","sequence":"additional","affiliation":[{"name":"Department of Women and Child Health Hospital for Children and Adolescents University Hospital Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freerk","family":"Prenzel","sequence":"additional","affiliation":[{"name":"Department of Women and Child Health Hospital for Children and Adolescents University Hospital Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Siekmeyer","sequence":"additional","affiliation":[{"name":"Department of Women and Child Health Hospital for Children and Adolescents University Hospital Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Michael","family":"Hau","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplantation, Thoracic and Vascular Surgery University Hospital Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wieland","family":"Kiess","sequence":"additional","affiliation":[{"name":"Department of Women and Child Health Hospital for Children and Adolescents University Hospital Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bartels","sequence":"additional","affiliation":[{"name":"Department of Visceral, Transplantation, Thoracic and Vascular Surgery University Hospital Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000007533"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.09.091"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21070"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00259.x"},{"key":"e_1_2_5_6_1","first-page":"17","article-title":"The Pitt\u2010UNOS liver transplant registry","author":"Belle SH","year":"1992","journal-title":"Clin Transpl"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-0012.1994.tb00933.x","article-title":"Restoration of exocrine pancreatic function following pancreas\u2010liver\u2010kidney transplantation in a cystic fibrosis patient","volume":"8","author":"Stern RC","year":"1994","journal-title":"Clin 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