{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:02:39Z","timestamp":1788397359367,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Renal impairment is frequently compromised in patients with end\u2010stage liver disease and is associated with increased long\u2010term mortality post\u2010LT. In contrast to CNI, basiliximab is an immunosuppressive agent with minimal nephrotoxic potential. This study reviews the experience of a single pediatric liver transplant center's renal\u2010sparing approach with the use of basiliximab and MMF to compensate for delayed entry of CNI in children with renal impairment at the time of organ availability. There were no differences in renal function between pediatric patients with and without pre\u2010LT renal impairment within the first year (<jats:styled-content style=\"fixed-case\">cGFR<\/jats:styled-content>: 135\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> vs. 144\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>; p\u00a0=\u00a00.56) or at 5\u20138\u00a0yr following LT, (129\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> vs. 130\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>; p\u00a0=\u00a00.97). In addition, there was no difference in ACR rates (50% vs. 43%, p\u00a0=\u00a00.62) between patients in the basiliximab group and those patients receiving standard CNI and steroid strategies. The utilization of a renal\u2010sparing approach with basiliximab alongside delayed entry and lower early target trough levels of <jats:styled-content style=\"fixed-case\">CNI<\/jats:styled-content> in children with renal impairment at the time of <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> is safe and maintains excellent long\u2010term kidney function.<\/jats:p>","DOI":"10.1111\/petr.12158","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:39:51Z","timestamp":1381541991000},"page":"751-756","source":"Crossref","is-referenced-by-count":18,"title":["Basiliximab with delayed introduction of calcineurin inhibitors as a renal\u2010sparing protocol following liver transplantation in children with renal impairment"],"prefix":"10.1111","volume":"17","author":[{"given":"M.","family":"Mouzaki","sequence":"first","affiliation":[{"name":"SickKids Transplant Centre The Hospital for Sick Children University of Toronto Toronto ON 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