{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:10:31Z","timestamp":1779253831450,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>\n \n The significance of\n HHV<\/jats:styled-content>\n 6\n DNA<\/jats:styled-content>\n emia after solid organ transplantation has not been fully determined. Our objectives were to determine the prevalence of\n HHV<\/jats:styled-content>\n 6\n DNA<\/jats:styled-content>\n emia in pediatric liver transplant recipients and to describe the associated clinical characteristics and outcomes. This was a retrospective case\u2013control study. Eligible liver transplant patients aged\u00a0\u2264\u00a018\u00a0yr with\n HHV<\/jats:styled-content>\n 6\n DNA<\/jats:styled-content>\n emia were matched with two subjects without\n HHV<\/jats:styled-content>\n 6\n DNA<\/jats:styled-content>\n emia. Matching was by age\u00a0\u00b1\u00a06\u00a0months. Among 154 subjects, 25 patients (16%) had\n HHV<\/jats:styled-content>\n 6\n DNA<\/jats:styled-content>\n emia detected by\n PCR<\/jats:styled-content>\n in whole blood or plasma (M:F ratio\u00a0=\u00a00.9:1). While 28% of subjects with\n DNA<\/jats:styled-content>\n emia (7\/25) had symptoms consistent with\n HHV<\/jats:styled-content>\n 6 infection, active infection was detected in only four subjects (2.6% of liver transplant patients). The major symptoms\/signs were fever, vomiting, lethargy, splenomegaly, bone marrow suppression, and elevated transaminases. The prevalence of\n DNA<\/jats:styled-content>\n emia due to other herpesviruses in cases vs. controls was\n EBV<\/jats:styled-content>\n 56% vs. 60%,\n CMV<\/jats:styled-content>\n 12% vs. 12%,\n HHV<\/jats:styled-content>\n 7 20% vs. 12%; p value is not significant for all pairwise comparisons.\n HHV<\/jats:styled-content>\n 6\n DNA<\/jats:styled-content>\n emia in pediatric liver transplant patients is not an uncommon entity. While the clinical relevance is still not entirely established, active\n HHV<\/jats:styled-content>\n 6 infection and attributable symptoms are relatively rare.\n <\/jats:p>","DOI":"10.1111\/petr.12176","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T03:02:46Z","timestamp":1383102166000},"page":"47-51","source":"Crossref","is-referenced-by-count":14,"title":["Clinical consequences of human herpesvirus\u20106\n DNA<\/scp>\n emia in peripheral blood in pediatric liver transplant recipients"],"prefix":"10.1111","volume":"18","author":[{"given":"Tariq","family":"Al Fawaz","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Hospital for Sick Children University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition Hospital for Sick Children University of Toronto Toronto ON Canada"},{"name":"Transplant Centre, Department of Pediatrics Hospital for Sick Children University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Richardson","sequence":"additional","affiliation":[{"name":"The Division of Microbiology Department of Pediatric Laboratory Medicine Hospital for Sick Children University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Barton","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Hospital for Sick Children University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Upton","family":"Allen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Hospital for Sick Children University of Toronto Toronto ON Canada"},{"name":"Transplant Centre, Department of Pediatrics Hospital for Sick Children University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,30]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"20","article-title":"Human herpes virus 6: A clinical update","volume":"13","author":"Zerr DM","year":"2006","journal-title":"Herpes"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02725664"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2000.00129.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-3046.2003.00099.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000229938.12722.ee"},{"key":"e_1_2_6_7_1","unstructured":"SinghN ChangFY GayowskiT et al.Fever in Liver Transplant Recipients in the 1990's: Changing spectrum of etiologic \u2013 Abstract Ja5. 37th Interscience Conference on Antimicrobial Agents and Chemotherapy Sept 1997."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199709150-00002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200006270-00015"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2003.00028.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v2.i9.345"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703153"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.9.3274-3279.2000"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-0934(01)00390-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.12.019"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1571-1574.2006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200202270-00021"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2000.tb02058.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/317929"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1128\/jvi.67.11.6768-6777.1993","article-title":"Activation of the Epstein\u2010Barr virus replicative cycle by human herpesvirus 6","volume":"67","author":"Flamad L","year":"1993","journal-title":"J Virol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/503434"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12106"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01310.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.05.083"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000261705.78595.98"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703423"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2002.040101.x"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12176","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.12176","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:49:21Z","timestamp":1779252561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,30]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/petr.12176"],"URL":"https:\/\/doi.org\/10.1111\/petr.12176","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,30]]}}}