{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:10:48Z","timestamp":1779253848860,"version":"3.51.4"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Appropriate hypothermic packaging techniques are an essential part of organ procurement. We present a case in which deviation from standard packaging practice may have caused sub\u2010zero storage temperatures during transport, resulting in a clinical picture resembling PNF. An 18\u2010month\u2010old male with alpha\u20101\u2010antitrypsin deficiency underwent liver transplant from a size\u2010matched pediatric donor. Upon arrival at the recipient hospital, ice crystals were noted in the UW solution. The transplant proceeded uneventfully with short ischemia times. Surprisingly, transaminases, INR, and total bilirubin were markedly elevated in the postoperative period but returned to near normal by discharge. Follow\u2010up of over five\u00a0yr has demonstrated normal liver function. Upon review, it was discovered that organ packaging during recovery included storage in the first bag with only 400\u00a0mL of UW solution, and pure ice in the second bag instead of slush. This suggests that the postoperative delayed graft function was related to sub\u2010zero storage of the graft during transport. This is the first report of sub\u2010zero cold injury, or frostbite, following inappropriate packaging of an otherwise healthy donor liver. The clinical picture closely resembled PNF, perhaps implicating this mechanism in other unexpected cases of graft non\u2010function.<\/jats:p>","DOI":"10.1111\/petr.12178","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T01:13:01Z","timestamp":1382058781000},"source":"Crossref","is-referenced-by-count":1,"title":["Frostbite of the liver: An unrecognized cause of primary non\u2010function?"],"prefix":"10.1111","volume":"18","author":[{"given":"Kristina","family":"Potanos","sequence":"first","affiliation":[{"name":"Department of Surgery and Pediatric Transplant Center Boston Children's Hospital and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heung Bae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery and Pediatric Transplant Center Boston Children's Hospital and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,18]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Guidance for Industry: Sanitary Transportation of Food","author":"FDA","year":"2010"},{"key":"e_1_2_6_3_1","volume-title":"Policy 3.6: Organ Distribution: Allocation of Livers","author":"HRSA OPTN","year":"2013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000195903.12999.bc"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703692"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199004000-00017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.20707.x"},{"key":"e_1_2_6_8_1","volume-title":"Policy 5.0: Standardized Packaging, Labeling, and Transporting of Organs, Vessels, and Tissue Typing Materials","author":"UNOS","year":"2010"}],"container-title":["Pediatric Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpetr.12178","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/petr.12178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/petr.12178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:50:04Z","timestamp":1779252604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/petr.12178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,18]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/petr.12178"],"URL":"https:\/\/doi.org\/10.1111\/petr.12178","archive":["Portico"],"relation":{},"ISSN":["1397-3142","1399-3046"],"issn-type":[{"value":"1397-3142","type":"print"},{"value":"1399-3046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,18]]}}}