{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:53:21Z","timestamp":1781312001428,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T00:00:00Z","timestamp":1385337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T00:00:00Z","timestamp":1385337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Even if kidney graft survival has improved during the last decades, sensitized pediatric patients are an emerging problem. We describe a 17\u2010yr\u2010old male who lost his first graft due to chronic rejection becoming hyperimmunized (\n                    <jats:styled-content style=\"fixed-case\">CDC PRA<\/jats:styled-content>\n                    99.61%). A desensitization protocol based on high\u2010dose\n                    <jats:styled-content style=\"fixed-case\">IVIG<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>\n                    , and two Mabthera\n                    <jats:sup>\u00ae<\/jats:sup>\n                    infusions was performed with minor response (\n                    <jats:styled-content style=\"fixed-case\">CDC PRA<\/jats:styled-content>\n                    post\u2010desensitization 80%). One\u00a0month after his second non\u2010living transplant, he developed a biopsy\u2010proven\n                    <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>\n                    ; post\u2010transplant immunological monitoring showed the presence of donor\u2010specific anti\u2010\n                    <jats:styled-content style=\"fixed-case\">DQ<\/jats:styled-content>\n                    5 antibodies (\n                    <jats:styled-content style=\"fixed-case\">DSA<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">MFI<\/jats:styled-content>\n                    20.000). He received methylprednisolone pulses and 45\n                    <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>\n                    sessions without clinical response; eculizumab was then used to salvage a kidney undergoing severe\n                    <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>\n                    \u2010resistant rejection. A biopsy performed after the fourth eculizumab infusion showed complete resolution of\n                    <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>\n                    . Eculizumab infusions were then continued for the first year post\u2010transplantation. Two yr after transplantation, graft function is stable. Anti\u2010C5 therapy may represent an effective therapeutic option in pediatric patients with\n                    <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>\n                    \u2010resistant\n                    <jats:styled-content style=\"fixed-case\">AMR<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/petr.12187","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T07:41:50Z","timestamp":1385365310000},"source":"Crossref","is-referenced-by-count":21,"title":["Plasmapheresis\u2010resistant acute humoral rejection successfully treated with anti\u2010C5 antibody"],"prefix":"10.1111","volume":"18","author":[{"given":"Giulia","family":"Ghirardo","sequence":"first","affiliation":[{"name":"Pediatric Nephrology, Dialysis and Transplant Unit Department of Pediatrics University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Benetti","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Dialysis and Transplant Unit Department of Pediatrics University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Poli","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Department Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Organ and Tissue Transplantation Immunology Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Vidal","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Dialysis and Transplant Unit Department of Pediatrics University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Della Vella","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Laboratory of Immunopathology and Molecular Biology of the Kidney University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Transplantation Immunology University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Murer","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology, Dialysis and Transplant Unit Department of Pediatrics University Hospital of Padua Padua Italy"},{"name":"Department of Pediatrics Laboratory of Immunopathology and Molecular Biology of the Kidney University Hospital of Padua Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2011.01638.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1386-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200009270-00006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182145306"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"191","article-title":"Risk of severe bacterial infections after anti\u2010CD20 treatment in paediatric patients with idiopathic nephrotic syndrome and kidney transplant recipients","volume":"24","author":"Meneghesso D","year":"2011","journal-title":"Transpl 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