{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:34:36Z","timestamp":1792074876581,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>\n \n r\n ATG<\/jats:styled-content>\n is used for\n HT<\/jats:styled-content>\n x induction but is costly and associated with infection and\n PTLD<\/jats:styled-content>\n . Hypothesis: Tailoring r\n ATG<\/jats:styled-content>\n induction with\n CD<\/jats:styled-content>\n 3 monitoring results in less infection, reduced costs, and similar rejection. Retrospective review of\n HT<\/jats:styled-content>\n x recipients receiving r\n ATG<\/jats:styled-content>\n induction. Control cases received \u201cusual\u201d r\n ATG<\/jats:styled-content>\n dosing (1.5\u00a0mg\/kg\/day typically\u00a0\u00d7\u00a05\u00a0days). Starting in\n O<\/jats:styled-content>\n ctober 2009, absolute\n CD<\/jats:styled-content>\n 3 monitoring (target <25\u00a0cells\/mm\n 3<\/jats:sup>\n ) guided r\n ATG<\/jats:styled-content>\n dosing (study cases). Outcomes included first\u2010year incidence of infection\/rejection, direct costs of therapy, and incidence of\n PTLD<\/jats:styled-content>\n \/death. Study cases (n\u00a0=\u00a032) received fewer doses of r\n ATG<\/jats:styled-content>\n (median 4 vs. 5, p\u00a0<\u00a00.001) and less total r\n ATG<\/jats:styled-content>\n (median 3.2 vs. 7.4\u00a0mg\/kg, p\u00a0<\u00a00.001) compared with controls (n\u00a0=\u00a017). There was no difference in incidence of infection, rejection, or patient survival during the first year post\u2010\n HT<\/jats:styled-content>\n x. There was one early death in both groups and one late case of\n PTLD<\/jats:styled-content>\n in the control group. Drug savings were significant (median drug cost per patient $2718 vs. $4756, p\u00a0<\u00a00.001). CD3\u2010tailored r\n ATG<\/jats:styled-content>\n induction in\n HT<\/jats:styled-content>\n x recipients is associated with reduced drug costs and similar rates of rejection\/infection. Longer follow\u2010up will determine whether extended benefits are associated with this induction monitoring strategy.\n <\/jats:p>","DOI":"10.1111\/petr.12193","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T08:56:47Z","timestamp":1385542607000},"page":"79-86","source":"Crossref","is-referenced-by-count":11,"title":["Role for immune monitoring to tailor induction prophylaxis in pediatric heart recipients"],"prefix":"10.1111","volume":"18","author":[{"given":"Philip T.","family":"Thrush","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ann & Robert H. Lurie Children's Hospital Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey G.","family":"Gossett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ann & Robert H. 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