{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T22:21:21Z","timestamp":1788128481741,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,28]],"date-time":"2013-12-28T00:00:00Z","timestamp":1388188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune and allergic diseases cause morbidity and diminished quality of life in pediatric organ transplant recipients. We hypothesize that younger age at transplantation and immunosuppression regimen play a role in the development of immune\u2010mediated disease following heart transplant. A single institution retrospective review identified all patients undergoing heart transplant at \u226418\u00a0yr of age from 1987 to 2010 who survived \u22651\u00a0yr. Using medical record and database review, patients were evaluated for development of autoimmune or severe allergic disease. Of 129 patients who met criteria, seven patients (5.4%) with autoimmune or severe atopic disease were identified. Immune\u2010mediated diseases included inflammatory bowel disease (n\u00a0=\u00a03), eosinophilic esophagitis\/colitis (n\u00a0=\u00a04), and chronic bullous disease of childhood (n\u00a0=\u00a01). Patients &lt;1\u00a0yr of age at transplant were at greater risk of developing autoimmune disease than patients 1\u201318\u00a0yr at transplant (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a09.3, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u201379.2, p\u00a0=\u00a00.02). All affected patients underwent thymectomy at &lt;1\u00a0yr of age (7\/71 vs. 0\/58, p\u00a0=\u00a00.02). In our experience, heart transplantation in infancy is associated with the development of immune\u2010mediated gastrointestinal and dermatologic diseases. Further study is needed to determine risk factors for the development of immune\u2010mediated disease to identify best practices to decrease incidence.<\/jats:p>","DOI":"10.1111\/petr.12205","type":"journal-article","created":{"date-parts":[[2013,12,28]],"date-time":"2013-12-28T08:01:47Z","timestamp":1388217707000},"page":"197-203","source":"Crossref","is-referenced-by-count":19,"title":["Clinical predictors of autoimmune and severe atopic disease in pediatric heart transplant recipients"],"prefix":"10.1111","volume":"18","author":[{"given":"Jessica H.","family":"Mouledoux","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Albers","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics University of Washington Seattle Children's Hospital Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin R.","family":"Saville","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology Department of Pediatrics Vanderbilt University Medical Center Nashville TN USA"},{"name":"Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra A.","family":"Dodd","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2006.03.011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.09.055"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.10.018"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2005.00474.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.22203.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00538.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000147735.19342.DE"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.08.023"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03771.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-341396"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39269"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.3.1962"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2009.01143.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.387"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.8.2694"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.11.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.04.011"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.06.043"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01304.x"}],"container-title":["Pediatric 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