{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:36:04Z","timestamp":1791351364699,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,28]],"date-time":"2013-12-28T00:00:00Z","timestamp":1388188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Transplantation"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> has been reported in 8\u201310% of children after small bowel transplant (<jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x). Immunodeficient children may be predisposed to aggressive, steroid\u2010resistant <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>. There exists a unique association of immunodeficiency in children with MIA (<jats:styled-content style=\"fixed-case\">MIAI<\/jats:styled-content>). We report on our <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x experience in patients with the diagnosis of <jats:styled-content style=\"fixed-case\">MIAI<\/jats:styled-content>, their high incidence of <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>, and the possible role of stem cell transplantation in these patients. We performed a review of records from children that underwent <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x or that we evaluated for <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x at our institution. We focused on the diagnoses of atresia, multiple intestinal atresia, immunodeficiency, and <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> in our patient population. Children with <jats:styled-content style=\"fixed-case\">MIAI<\/jats:styled-content> are likely to experience severe <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> following <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x. <jats:styled-content style=\"fixed-case\">MIAI<\/jats:styled-content> correlated with a 100% incidence of <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> in these patients. Of the five patients with <jats:styled-content style=\"fixed-case\">MIAI<\/jats:styled-content> that underwent <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x, three succumbed to severe <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> within 1\u20136\u00a0months after <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x. One patient received stem cell transplant prior to <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x and did not develop severe <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>, but died from influenza nine\u00a0months after <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x. Our unique patient survives long\u2010term, with engraftment of donor \u03b3 \u03b4 T cells. He has mild, persistent chronic <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>. Atresia is a common referral diagnosis for <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x. Patients with multiple atresias, especially <jats:styled-content style=\"fixed-case\">MIAI<\/jats:styled-content>, are at significant risk for the complication of <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content> following <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x. We recommend careful immunologic assessment and antecedent stem cell transplant in children with <jats:styled-content style=\"fixed-case\">MIAI<\/jats:styled-content> prior to <jats:styled-content style=\"fixed-case\">SBT<\/jats:styled-content>x.<\/jats:p>","DOI":"10.1111\/petr.12211","type":"journal-article","created":{"date-parts":[[2013,12,28]],"date-time":"2013-12-28T08:01:21Z","timestamp":1388217681000},"page":"190-196","source":"Crossref","is-referenced-by-count":30,"title":["Intestinal transplantation in children with multiple intestinal atresias and immunodeficiency"],"prefix":"10.1111","volume":"18","author":[{"given":"Ryan T.","family":"Fischer","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology Children's Mercy Hospital Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Friend","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mattel Children's Hospital Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey A.","family":"Talmon","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy J.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben E.","family":"Quiros\u2010Tejeira","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan N.","family":"Langnas","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Coccia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00524.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31817b912e"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(73)90401-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-101483"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.01.017"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.01.031"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1187"},{"key":"e_1_2_10_9_1","unstructured":"Intestinal Transplants in U.S. by State. 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